Allosensitization in patients receiving multiple blood transfusions

Vishwas S. Sakhalkar, K. Roberts, L. M. Hawthorne, D. M. McCaskill, D. M. Veillon, G. G. Caldito, J. D. Cotelingam

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and $153 extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalAnnals of the New York Academy of Sciences
StatePublished - 2005
Externally publishedYes


  • Allergic
  • Alloantibody
  • Allosensitization
  • Autoantibody
  • Extended crossmatch
  • Febrile
  • Multiple blood transfusions
  • Transfusion reactions

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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