Allosensitization in patients receiving multiple blood transfusions

Vishwas S. Sakhalkar; K. Roberts; L. M. Hawthorne; D. M. McCaskill; D. M. Veillon; G. G. Caldito; J. D. Cotelingam

doi:10.1196/annals.1345.072

Allosensitization in patients receiving multiple blood transfusions

Vishwas S. Sakhalkar, K. Roberts, L. M. Hawthorne, D. M. McCaskill, D. M. Veillon, G. G. Caldito, J. D. Cotelingam

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and $153 extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.

Original language	English (US)
Pages (from-to)	495-499
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1054
DOIs	https://doi.org/10.1196/annals.1345.072
State	Published - 2005
Externally published	Yes

Keywords

Allergic
Alloantibody
Allosensitization
Autoantibody
Extended crossmatch
Febrile
Multiple blood transfusions
Transfusion reactions

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1196/annals.1345.072

Cite this

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title = "Allosensitization in patients receiving multiple blood transfusions",

abstract = "Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and $153 extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.",

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T1 - Allosensitization in patients receiving multiple blood transfusions

AU - Sakhalkar, Vishwas S.

AU - Roberts, K.

AU - Hawthorne, L. M.

AU - McCaskill, D. M.

AU - Veillon, D. M.

AU - Caldito, G. G.

AU - Cotelingam, J. D.

PY - 2005

Y1 - 2005

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AB - Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and $153 extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.

KW - Allergic

KW - Alloantibody

KW - Allosensitization

KW - Autoantibody

KW - Extended crossmatch

KW - Febrile

KW - Multiple blood transfusions

KW - Transfusion reactions

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Allosensitization in patients receiving multiple blood transfusions

Abstract

Keywords

ASJC Scopus subject areas

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