Abstract
Background: The effects of allosteric modulators on G protein-coupled receptor trafficking are largely unknown. Results: The allosteric ligand BQCA modulates M1 mAChR arrestin recruitment and receptor trafficking. Conclusion: M1 mAChR trafficking is arrestin- and G protein-dependent and modulated by BQCA. Significance: The impact of allosteric modulators on receptor trafficking needs to be assessed when considering this family of ligands as potential chronic therapies.
Original language | English (US) |
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Pages (from-to) | 15856-15866 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 22 |
DOIs | |
State | Published - May 30 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology