Abstract
Denovo synthesis of alpha1-antitrypsin (α1AT) by human peripheral lymphocytes has been demonstrated in the present study. Treatment of the mononuclear cells with concanavalin A(Con A) resulted in a triple increase in the amount of α1AT synthesized by the untreated cells. A small amount of α1AT, equivalent to that synthesized by the unstimulated mononuclear cells, was observed in cultures of monocyte-depleted lymphocytes, with or without Con A stimulation. Monocytes treated with or without Con A scarcely synthesized α1AT. Conditioned media derived from monocyte enriched mononuclear cells treated with Con A enhanced about threefold α1AT synthesis by the Con A-stimulated lymphocytes. α1AT is suggested to be synthesized by lymphocytes assisted by monocytes.
Original language | English (US) |
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Pages (from-to) | 1509-1516 |
Number of pages | 8 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 104 |
Issue number | 4 |
DOIs | |
State | Published - Feb 26 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology