An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

J. Y. Zhao; M. M. Xiong; W. Huang; H. Wang; J. Zuo; G. D. Wu; Z. Chen; B. Q. Qiang; M. L. Zhang; J. L. Chen; W. Ding; W. T. Yuan; Hongyan Xu; L. Jin; Y. X. Li; Q. Sun; Q. Y. Liu; E. Boerwinkle; F. D. Fang

doi:10.1007/s00109-004-0587-3

An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

J. Y. Zhao, M. M. Xiong, W. Huang, H. Wang, J. Zuo, G. D. Wu, Z. Chen, B. Q. Qiang, M. L. Zhang, J. L. Chen, W. Ding, W. T. Yuan, Hongyan Xu, L. Jin, Y. X. Li, Q. Sun, Q. Y. Liu, E. Boerwinkle, F. D. Fang

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.

Original language	English (US)
Pages (from-to)	209-215
Number of pages	7
Journal	Journal of Molecular Medicine
Volume	83
Issue number	3
DOIs	https://doi.org/10.1007/s00109-004-0587-3
State	Published - Mar 2005
Externally published	Yes

Keywords

Linkage analysis
Type 2 diabetes
Whole-genome scan

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00109-004-0587-3

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Zhao, J. Y., Xiong, M. M., Huang, W., Wang, H., Zuo, J., Wu, G. D., Chen, Z., Qiang, B. Q., Zhang, M. L., Chen, J. L., Ding, W., Yuan, W. T., Xu, H., Jin, L., Li, Y. X., Sun, Q., Liu, Q. Y., Boerwinkle, E., & Fang, F. D. (2005). An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. Journal of Molecular Medicine, 83(3), 209-215. https://doi.org/10.1007/s00109-004-0587-3

Zhao, JY, Xiong, MM, Huang, W, Wang, H, Zuo, J, Wu, GD, Chen, Z, Qiang, BQ, Zhang, ML, Chen, JL, Ding, W, Yuan, WT, Xu, H, Jin, L, Li, YX, Sun, Q, Liu, QY, Boerwinkle, E & Fang, FD 2005, 'An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese', Journal of Molecular Medicine, vol. 83, no. 3, pp. 209-215. https://doi.org/10.1007/s00109-004-0587-3

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title = "An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese",

abstract = "We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.",

keywords = "Linkage analysis, Type 2 diabetes, Whole-genome scan",

author = "Zhao, {J. Y.} and Xiong, {M. M.} and W. Huang and H. Wang and J. Zuo and Wu, {G. D.} and Z. Chen and Qiang, {B. Q.} and Zhang, {M. L.} and Chen, {J. L.} and W. Ding and Yuan, {W. T.} and Hongyan Xu and L. Jin and Li, {Y. X.} and Q. Sun and Liu, {Q. Y.} and E. Boerwinkle and Fang, {F. D.}",

note = "Funding Information: Acknowledgements This work was supported by grants from the National Science Foundation of China (no. 30170441), the National High Technology Research and Development Program (no. 2001AA221161, no. 2002BA711A05, no. 2002BA711A10-02), the National Program for Key Basic Research Projects (no. G1998051016), and Natural Science Foundation of Beijing (no. 7002026)",

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doi = "10.1007/s00109-004-0587-3",

language = "English (US)",

volume = "83",

pages = "209--215",

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AU - Zhao, J. Y.

AU - Xiong, M. M.

AU - Huang, W.

AU - Wang, H.

AU - Zuo, J.

AU - Wu, G. D.

AU - Chen, Z.

AU - Qiang, B. Q.

AU - Zhang, M. L.

AU - Chen, J. L.

AU - Ding, W.

AU - Yuan, W. T.

AU - Xu, Hongyan

AU - Jin, L.

AU - Li, Y. X.

AU - Sun, Q.

AU - Liu, Q. Y.

AU - Boerwinkle, E.

AU - Fang, F. D.

N1 - Funding Information: Acknowledgements This work was supported by grants from the National Science Foundation of China (no. 30170441), the National High Technology Research and Development Program (no. 2001AA221161, no. 2002BA711A05, no. 2002BA711A10-02), the National Program for Key Basic Research Projects (no. G1998051016), and Natural Science Foundation of Beijing (no. 7002026)

PY - 2005/3

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N2 - We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.

AB - We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.

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An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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