An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin

Oe Kyung Kim; Akira Murakami; Daisuke Takahashi; Yoshimasa Nakamura; Koji Torikai; Ha Won Kim; Hajime Ohigashi

doi:10.1271/bbb.64.2504

An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin

Oe Kyung Kim, Akira Murakami, Daisuke Takahashi, Yoshimasa Nakamura, Koji Torikai, Ha Won Kim, Hajime Ohigashi

Cardiology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide- and interferon-γ-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20 μM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H₂O₂) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H₂O₂ generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.

Original language	English (US)
Pages (from-to)	2504-2507
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	64
Issue number	11
DOIs	https://doi.org/10.1271/bbb.64.2504
State	Published - 2000

Keywords

Cyclooxygenase-2
Hydrogen peroxide
Inducible nitric oxide synthase
Persenone A

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.64.2504

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Kim, O. K., Murakami, A., Takahashi, D., Nakamura, Y., Torikai, K., Kim, H. W., & Ohigashi, H. (2000). An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin. Bioscience, Biotechnology and Biochemistry, 64(11), 2504-2507. https://doi.org/10.1271/bbb.64.2504

An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin. / Kim, Oe Kyung; Murakami, Akira; Takahashi, Daisuke et al.
In: Bioscience, Biotechnology and Biochemistry, Vol. 64, No. 11, 2000, p. 2504-2507.

Research output: Contribution to journal › Article › peer-review

Kim, OK, Murakami, A, Takahashi, D, Nakamura, Y, Torikai, K, Kim, HW & Ohigashi, H 2000, 'An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin', Bioscience, Biotechnology and Biochemistry, vol. 64, no. 11, pp. 2504-2507. https://doi.org/10.1271/bbb.64.2504

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abstract = "We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide- and interferon-γ-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20 μM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H2O2) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H2O2 generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.",

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AU - Kim, Oe Kyung

AU - Murakami, Akira

AU - Takahashi, Daisuke

AU - Nakamura, Yoshimasa

AU - Torikai, Koji

AU - Kim, Ha Won

AU - Ohigashi, Hajime

PY - 2000

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N2 - We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide- and interferon-γ-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20 μM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H2O2) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H2O2 generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.

AB - We investigated the suppressive effects of an avocado constituent, persenone A, on lipopolysaccharide- and interferon-γ-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in a mouse macrophage cell line RAW 264.7. Persenone A at concentration of 20 μM almost completely suppressed both iNOS and COX-2 protein expression. In mouse skin, double treatments with persenone A (810 nmol) significantly suppressed double 12-O-tetradecanoylphorbol-13-acetate (TPA, 8.1 nmol) application-induced hydrogen peroxide (H2O2) generation. Treatment with persenone A before the second TPA treatment was sufficient to inhibit H2O2 generation, while the first treatment was not. This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer.

KW - Cyclooxygenase-2

KW - Hydrogen peroxide

KW - Inducible nitric oxide synthase

KW - Persenone A

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An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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