An emergency response team for membrane repair

Paul L. McNeil, Tom Kirchhausen

Research output: Contribution to journalReview articlepeer-review

296 Scopus citations


On demand, rapid Ca2+-triggered homotypic and exocytic membrane-fusion events are required to repair a torn plasma membrane, and we propose that this emergency-based fusion differs fundamentally from other rapid, triggered fusion reactions. Emergency fusion might use a specialized protein and organelle emergency response team that can simultaneously promote impromptu homotypic fusion events between organelles and exocytic fusion events along the vertices between these fusion products and the plasma membrane.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalNature Reviews Molecular Cell Biology
Issue number6
StatePublished - Jun 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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