An essential role of Bmp4 in the atrioventricular septation of the mouse heart

Kai Jiao, Holger Kulessa, Kevin Tompkins, Yingna Zhou, Lorene Batts, H. Scott Baldwin, Brigid L.M. Hogan

Research output: Contribution to journalArticlepeer-review

294 Scopus citations

Abstract

Proper septation and valvulogenesis during cardiogenesis depend on interactions between the myocardium and the endocardium. By combining use of a hypomorphic Bone morphogenetic protein 4 (Bmp4) allele with conditional gene inactivation, we here identify Bmp4 as a signal from the myocardium directly mediating atrioventricular septation. Defects in this process cause one of the most common human congenital heart abnormalities, atrioventricular canal defect (AVCD). The spectrum of defects obtained through altering Bmp4 expression in the myocardium recapitulates the range of AVCDs diagnosed in patients, thus providing a useful genetic model with AVCD as the primary defect.

Original languageEnglish (US)
Pages (from-to)2362-2367
Number of pages6
JournalGenes and Development
Volume17
Issue number19
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

Keywords

  • Atrioventricular septation
  • Bmp4
  • Cardiogenesis

ASJC Scopus subject areas

  • General Medicine

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