An unconventional role of neurotransmission in synapse formation

Wen C. Xiong; Lin Mei

doi:10.1016/j.neuron.2005.05.008

An unconventional role of neurotransmission in synapse formation

Wen C. Xiong, Lin Mei

Graduate Studies

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

How do presynatic inputs regulate synapse formation? In this issue of Neuron, Lin et al. show that the neurotransmitter acetylcholine decreases the stability of AChR clusters. This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction.

Original language	English (US)
Pages (from-to)	521-523
Number of pages	3
Journal	Neuron
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2005.05.008
State	Published - May 19 2005

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2005.05.008

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title = "An unconventional role of neurotransmission in synapse formation",

abstract = "How do presynatic inputs regulate synapse formation? In this issue of Neuron, Lin et al. show that the neurotransmitter acetylcholine decreases the stability of AChR clusters. This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction.",

author = "Xiong, {Wen C.} and Lin Mei",

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AB - How do presynatic inputs regulate synapse formation? In this issue of Neuron, Lin et al. show that the neurotransmitter acetylcholine decreases the stability of AChR clusters. This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction.

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JO - Neuron

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An unconventional role of neurotransmission in synapse formation

Abstract

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