Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell

C. Templin; A. R. Simon; C. Schröder; M. E. Winkler; G. Laaf; M. Chikobava; V. Z. Agrba; B. A. Lapin; A. Haverich; U. Martin

Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell

Translated title of the contribution: Analysis of potential PERV infection in a clinical-relevant pig to baboon xenotransplantation model

C. Templin
, A. R. Simon
, C. Schröder
, M. E. Winkler
, G. Laaf
, M. Chikobava
, V. Z. Agrba
, B. A. Lapin
, A. Haverich
, U. Martin

Research output: Contribution to journal › Article › peer-review

Abstract

Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.

Translated title of the contribution	Analysis of potential PERV infection in a clinical-relevant pig to baboon xenotransplantation model
Original language	German
Pages (from-to)	225-230
Number of pages	6
Journal	Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft
Volume	14
Issue number	4
State	Published - 2002
Externally published	Yes

Keywords

Baboon
Infection risk
PERV
Porcine endogenous retrovirus
Xenotransplantation

ASJC Scopus subject areas

Transplantation

Cite this

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title = "Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell",

abstract = "Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.",

keywords = "Baboon, Infection risk, PERV, Porcine endogenous retrovirus, Xenotransplantation",

author = "C. Templin and Simon, \{A. R.\} and C. Schr{\"o}der and Winkler, \{M. E.\} and G. Laaf and M. Chikobava and Agrba, \{V. Z.\} and Lapin, \{B. A.\} and A. Haverich and U. Martin",

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language = "German",

volume = "14",

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journal = "Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft",

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TY - JOUR

T1 - Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell

AU - Templin, C.

AU - Simon, A. R.

AU - Schröder, C.

AU - Winkler, M. E.

AU - Laaf, G.

AU - Chikobava, M.

AU - Agrba, V. Z.

AU - Lapin, B. A.

AU - Haverich, A.

AU - Martin, U.

PY - 2002

Y1 - 2002

N2 - Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.

AB - Besides vehement rejection of pig organs, infection risks, especially the risk of porcine endogenous retrovirus (PERV) transmission, represent the main hurdle for clinical introduction of xenotransplantation. Neither retrospective studies on patients nor small animal models mirror settings of clinical xenotransplantation very closely. For this reason, we have analysed the PERV infection risk in a pig-to-baboon xenotransplantation model after conditioning CyP immunosuppression, adsorption of anti-porcine antibodies and inactivation of complement.

KW - Baboon

KW - Infection risk

KW - PERV

KW - Porcine endogenous retrovirus

KW - Xenotransplantation

UR - https://www.scopus.com/pages/publications/0036962243

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M3 - Article

AN - SCOPUS:0036962243

SN - 0946-9648

VL - 14

SP - 225

EP - 230

JO - Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

JF - Transplantationsmedizin: Organ der Deutschen Transplantationsgesellschaft

IS - 4

ER -

Analyse potentieller PERV-infektionen in einem klinisch relevanten schwein-auf-pavian-zelltransplantationsmodell

Abstract

Keywords

ASJC Scopus subject areas

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