Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases

Kent R. Nilsson; Vann Bennett

doi:10.1097/FJC.0b013e3181b2b6ed

Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases

Kent R. Nilsson, Vann Bennett

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

Original language	English (US)
Pages (from-to)	106-115
Number of pages	10
Journal	Journal of Cardiovascular Pharmacology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1097/FJC.0b013e3181b2b6ed
State	Published - Aug 2009
Externally published	Yes

Keywords

Adherens junction
Ankyrin-B
Ankyrin-G
Arrhythmogenic right ventricular cardiomyopathy
Brugada
Costamere
Desmosome
Intercalated disc
Long QT syndrome

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/FJC.0b013e3181b2b6ed

Cite this

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title = "Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases",

abstract = "The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.",

keywords = "Adherens junction, Ankyrin-B, Ankyrin-G, Arrhythmogenic right ventricular cardiomyopathy, Brugada, Costamere, Desmosome, Intercalated disc, Long QT syndrome",

author = "Nilsson, {Kent R.} and Vann Bennett",

year = "2009",

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doi = "10.1097/FJC.0b013e3181b2b6ed",

language = "English (US)",

volume = "54",

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journal = "Journal of Cardiovascular Pharmacology",

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T1 - Ankyrin-based patterning of membrane microdomains

T2 - New insights into a novel class of cardiovascular diseases

AU - Nilsson, Kent R.

AU - Bennett, Vann

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N2 - The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

AB - The organization of membrane-spanning proteins within discrete microdomains is critical for their physiologic function. This is especially important in the heart, where ion transporter and forcetransducing microdomains are responsible for excitation-contraction coupling, anisotropic depolarization, and mechanotransduction. The following review will discuss recent advances in our understanding of the patterning of ion channel and force-transmitting membrane microdomains in cardiomyocytes, focusing on the T-tubule and intercalated disc.

KW - Adherens junction

KW - Ankyrin-B

KW - Ankyrin-G

KW - Arrhythmogenic right ventricular cardiomyopathy

KW - Brugada

KW - Costamere

KW - Desmosome

KW - Intercalated disc

KW - Long QT syndrome

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DO - 10.1097/FJC.0b013e3181b2b6ed

M3 - Review article

C2 - 19636256

AN - SCOPUS:74249116009

SN - 0160-2446

VL - 54

SP - 106

EP - 115

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

IS - 2

ER -

Ankyrin-based patterning of membrane microdomains: New insights into a novel class of cardiovascular diseases

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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