Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids

Koichi Node, Yuqing Huo, Xiulu Ruan, Baichun Yang, Martin Spiecker, Klaus Ley, Darryl C. Zeldin, James K. Liao

Research output: Contribution to journalArticlepeer-review

1052 Scopus citations


The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase. The inhibitory effects of EETs were independent of their membrane- hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.

Original languageEnglish (US)
Pages (from-to)1276-1279
Number of pages4
Issue number5431
StatePublished - Aug 20 1999

ASJC Scopus subject areas

  • General


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