Abstract
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450 isoform CYP2J2 was cloned and identified as a potential source of EETs in human endothelial cells. Physiological concentrations of EETs or overexpression of CYP2J2 decreased cytokine-induced endothelial cell adhesion molecule expression, and EETs prevented leukocyte adhesion to the vascular wall by a mechanism involving inhibition of transcription factor NF-κB and IκB kinase. The inhibitory effects of EETs were independent of their membrane- hyperpolarizing effects, suggesting that these molecules play an important nonvasodilatory role in vascular inflammation.
Original language | English (US) |
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Pages (from-to) | 1276-1279 |
Number of pages | 4 |
Journal | Science |
Volume | 285 |
Issue number | 5431 |
DOIs | |
State | Published - Aug 20 1999 |
ASJC Scopus subject areas
- General