Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis

Amena Ben Younes-Chennoufi; Anne Rozier; Michel Dib; Pierre Bouche; lucette Lacomblez; Nina Mombo; Gilbert Ben Simon; Robert K. Yu; nicole Baumann; Vincent Meininger

doi:10.1016/0165-5728(94)00169-O

Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis

Amena Ben Younes-Chennoufi, Anne Rozier, Michel Dib, Pierre Bouche, lucette Lacomblez, Nina Mombo, Gilbert Ben Simon, Robert K. Yu, nicole Baumann, Vincent Meininger

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.

Original language	English (US)
Pages (from-to)	111-115
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	57
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(94)00169-O
State	Published - Mar 1995
Externally published	Yes

Keywords

Amyotrophic lateral sclerosis
IgM antibodies
Sulfated glucuronyl paragloboside

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/0165-5728(94)00169-O

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title = "Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis",

abstract = "We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.",

keywords = "Amyotrophic lateral sclerosis, IgM antibodies, Sulfated glucuronyl paragloboside",

author = "Younes-Chennoufi, {Amena Ben} and Anne Rozier and Michel Dib and Pierre Bouche and lucette Lacomblez and Nina Mombo and Simon, {Gilbert Ben} and Yu, {Robert K.} and nicole Baumann and Vincent Meininger",

year = "1995",

month = mar,

doi = "10.1016/0165-5728(94)00169-O",

language = "English (US)",

volume = "57",

pages = "111--115",

journal = "Journal of Neuroimmunology",

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T1 - Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis

AU - Younes-Chennoufi, Amena Ben

AU - Rozier, Anne

AU - Dib, Michel

AU - Bouche, Pierre

AU - Lacomblez, lucette

AU - Mombo, Nina

AU - Simon, Gilbert Ben

AU - Yu, Robert K.

AU - Baumann, nicole

AU - Meininger, Vincent

PY - 1995/3

Y1 - 1995/3

N2 - We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.

AB - We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.

KW - Amyotrophic lateral sclerosis

KW - IgM antibodies

KW - Sulfated glucuronyl paragloboside

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ER -

Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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