Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats

S. P. Ghosh, T. K. Chatterjee, J. J. Ghosh

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In ventral prostate tissues of adult castrated rats, delta-9-tetrahydrocannabinol (THC) at 10 mg/kg for 7 days counteracted the testosterone-induced changes of DNA, RNA and protein content, the tartrate-insensitive form of acid phosphatase, and the isoenzyme variant of acid phosphatase associated with the secretory type enzyme. The results indicate that THC acts anti-androgenically and directly at the level of male accessory sex organs.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalJournal of Reproduction and Fertility
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology


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