Antibodies to glycoconjugates in human motor neuron disease

Norman Latov; Arthur P. Hays; Robert K. Yu; Hiroaki Ito; Florian P. Thomas

doi:10.1007/BF03160145

Antibodies to glycoconjugates in human motor neuron disease

Norman Latov, Arthur P. Hays, Robert K. Yu, Hiroaki Ito, Florian P. Thomas

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.

Original language	English (US)
Pages (from-to)	181-187
Number of pages	7
Journal	Neurochemical Pathology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1007/BF03160145
State	Published - Jun 1988
Externally published	Yes

Keywords

Motor neurons, degeneration of
and gangliosides
autoimmune mechanisms
glycolipids
monoclonal antibodies

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF03160145

Cite this

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title = "Antibodies to glycoconjugates in human motor neuron disease",

abstract = "IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.",

keywords = "Motor neurons, degeneration of, and gangliosides, autoimmune mechanisms, glycolipids, monoclonal antibodies",

author = "Norman Latov and Hays, {Arthur P.} and Yu, {Robert K.} and Hiroaki Ito and Thomas, {Florian P.}",

year = "1988",

month = jun,

doi = "10.1007/BF03160145",

language = "English (US)",

volume = "8",

pages = "181--187",

journal = "Neurochemical Pathology",

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TY - JOUR

T1 - Antibodies to glycoconjugates in human motor neuron disease

AU - Latov, Norman

AU - Hays, Arthur P.

AU - Yu, Robert K.

AU - Ito, Hiroaki

AU - Thomas, Florian P.

PY - 1988/6

Y1 - 1988/6

N2 - IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.

AB - IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.

KW - Motor neurons, degeneration of

KW - and gangliosides

KW - autoimmune mechanisms

KW - glycolipids

KW - monoclonal antibodies

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DO - 10.1007/BF03160145

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JO - Neurochemical Pathology

JF - Neurochemical Pathology

IS - 3

ER -

Antibodies to glycoconjugates in human motor neuron disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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