Antidepressant effects on kinase gene expression patterns in rat brain

J. L. Rausch, C. F. Gillespie, Y. Fei, H. M. Hobby, T. Stoming, V. Ganapathy, F. H. Leibach

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.

Original languageEnglish (US)
Pages (from-to)91-94
Number of pages4
JournalNeuroscience Letters
Issue number2
StatePublished - Dec 13 2002
Externally publishedYes


  • Antidepressants
  • CAMP-mediated protein kinase
  • Citalopram
  • Fluoxetine
  • Janus protein kinase
  • Kinase
  • Phosphofructokinase
  • Phosphofructokinase M
  • Protein kinase
  • Protein kinase C
  • Serotonin
  • Serotonin transporter
  • Serotonin uptake
  • Stress-activated protein kinase

ASJC Scopus subject areas

  • Neuroscience(all)


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