Antidepressant effects on kinase gene expression patterns in rat brain

J. L. Rausch; C. F. Gillespie; Y. Fei; H. M. Hobby; T. Stoming; V. Ganapathy; F. H. Leibach

doi:10.1016/S0304-3940(02)01106-0

Antidepressant effects on kinase gene expression patterns in rat brain

J. L. Rausch, C. F. Gillespie, Y. Fei, H. M. Hobby, T. Stoming, V. Ganapathy, F. H. Leibach

Psychiatry and Health Behavior

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.

Original language	English (US)
Pages (from-to)	91-94
Number of pages	4
Journal	Neuroscience Letters
Volume	334
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)01106-0
State	Published - Dec 13 2002

Keywords

Antidepressants
CAMP-mediated protein kinase
Citalopram
Fluoxetine
Janus protein kinase
Kinase
Phosphofructokinase
Phosphofructokinase M
Protein kinase
Protein kinase C
Serotonin
Serotonin transporter
Serotonin uptake
Stress-activated protein kinase

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(02)01106-0

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title = "Antidepressant effects on kinase gene expression patterns in rat brain",

abstract = "Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.",

keywords = "Antidepressants, CAMP-mediated protein kinase, Citalopram, Fluoxetine, Janus protein kinase, Kinase, Phosphofructokinase, Phosphofructokinase M, Protein kinase, Protein kinase C, Serotonin, Serotonin transporter, Serotonin uptake, Stress-activated protein kinase",

author = "Rausch, {J. L.} and Gillespie, {C. F.} and Y. Fei and Hobby, {H. M.} and T. Stoming and V. Ganapathy and Leibach, {F. H.}",

note = "Funding Information: This work was supported by the Veterans Administration and NIMH Grant RO1 MH50366-05.",

year = "2002",

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doi = "10.1016/S0304-3940(02)01106-0",

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AU - Rausch, J. L.

AU - Gillespie, C. F.

AU - Fei, Y.

AU - Hobby, H. M.

AU - Stoming, T.

AU - Ganapathy, V.

AU - Leibach, F. H.

N1 - Funding Information: This work was supported by the Veterans Administration and NIMH Grant RO1 MH50366-05.

PY - 2002/12/13

Y1 - 2002/12/13

N2 - Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.

AB - Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We studied whole brain kinase mRNA expression on Affymetrix gene chips in rats treated with placebo 3 and 21 days, fluoxetine 3 and 21 days, and citalopram 21 days. Protein kinase C (PKC)-delta, PKC-gamma, stress-activated protein kinase, cAMP-dependent protein kinase beta isoform, Janus protein kinase, and phosphofructokinase M were all down regulated chronically with citalopram and fluoxetine, but not with acute fluoxetine. The results are consistent with homeostasis of SERT function through a decrease in PK expression.

KW - Antidepressants

KW - CAMP-mediated protein kinase

KW - Citalopram

KW - Fluoxetine

KW - Janus protein kinase

KW - Kinase

KW - Phosphofructokinase

KW - Phosphofructokinase M

KW - Protein kinase

KW - Protein kinase C

KW - Serotonin

KW - Serotonin transporter

KW - Serotonin uptake

KW - Stress-activated protein kinase

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Antidepressant effects on kinase gene expression patterns in rat brain

Abstract

Keywords

ASJC Scopus subject areas

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