Abstract
The secretion of gamma-interferon (IFN-γ), Interleukin-2 (IL-2), and B cell growth factor (BCGF) by human T cell clones specific for hepatitis B surface antigen (HBsAg) was examined. Antigenic stimulation by HBsAg but not by influenza A virus resulted in IFN-γ and BCGF synthesis by the T cell clones. No detectable amounts of IL-2 were obtained in the supernatants of any of the HBsAg-specific T cell clones when cultured in the presence or absence of antigen. IFN-γ and BCGF were produced, even when cell proliferation was inhibited, suggesting that the secretion of these T cell factors occured regardless of cell proliferation. The significance of the various factors in the immune response against hepatitis B virus infection is discussed.
Original language | English (US) |
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Pages (from-to) | 229-237 |
Number of pages | 9 |
Journal | Human Immunology |
Volume | 11 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1984 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology