TY - JOUR
T1 - Antihyperlipidemic potential of a polyherbal preparation on Triton WR 1339 (Tyloxapol) induced hyperlipidemia
T2 - A comparison with lovastatin
AU - Ansarullah,
AU - Jadeja, R.
AU - Thounaojam, M.
AU - Patel, V.
AU - Devkar, R.
AU - Ramachandran, A.
PY - 2009/4/1
Y1 - 2009/4/1
N2 - We investigated the antihyperlipidemic activity of an aqueous extract of a herbal preparation from a combination of six Indian medicinal plants. The current study was undertaken to assess the hypolipidemic, hypocholesterolemic and hypotriglyceridemic potential of the polyherbal extract using Triton WR 1339 (Tyloxapol) induced hyperlipidemia. The animals were divided into four groups'normal control, hyperlipidemic control, hyperlipidemic plus polyherbal extract and hyperlipidemic plus Lovastatin. Hyperlipidemia was induced by single intravenous injection of Triton WR 1339. Intragastric administration of polyherbal extract (500mg/kg of body weight) significantly decreased plasma cholesterol, triglyceride, non-HDL-C and phospholipids levels and increased HDL-C levels. Atherogenic index and triglyceride secretion rate were lowered in the polyherbal extract fed animals when compared to hyperlipidemic animals. Polyherbal extract exhibited quite competitive potential when compared with the reference drug Lovastatin affording a possible alternative therapeutic agent in the treatment of hyperlipidemia.
AB - We investigated the antihyperlipidemic activity of an aqueous extract of a herbal preparation from a combination of six Indian medicinal plants. The current study was undertaken to assess the hypolipidemic, hypocholesterolemic and hypotriglyceridemic potential of the polyherbal extract using Triton WR 1339 (Tyloxapol) induced hyperlipidemia. The animals were divided into four groups'normal control, hyperlipidemic control, hyperlipidemic plus polyherbal extract and hyperlipidemic plus Lovastatin. Hyperlipidemia was induced by single intravenous injection of Triton WR 1339. Intragastric administration of polyherbal extract (500mg/kg of body weight) significantly decreased plasma cholesterol, triglyceride, non-HDL-C and phospholipids levels and increased HDL-C levels. Atherogenic index and triglyceride secretion rate were lowered in the polyherbal extract fed animals when compared to hyperlipidemic animals. Polyherbal extract exhibited quite competitive potential when compared with the reference drug Lovastatin affording a possible alternative therapeutic agent in the treatment of hyperlipidemia.
KW - Hypercholesterolemia
KW - Polyherbal
KW - Triton WR 1339
UR - http://www.scopus.com/inward/record.url?scp=77649186018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649186018&partnerID=8YFLogxK
U2 - 10.4103/0973-8258.54900
DO - 10.4103/0973-8258.54900
M3 - Article
AN - SCOPUS:77649186018
SN - 0973-8258
VL - 3
SP - 119
EP - 124
JO - International Journal of Green Pharmacy
JF - International Journal of Green Pharmacy
IS - 2
ER -