Apoptosis Pathways and Chemotherapy in Brain Tumors

Monica Venere, Kuntal De, Ji Young Yoo, Balveen Kaur

Research output: Chapter in Book/Report/Conference proceedingChapter


Apoptosis, the major programed cell death pathway, is a mechanism of both normal homeostasis and disease. In the context of tumors, the apoptotic machinery is altered to favor tumor expansion despite harsh microenvironmental conditions and therapeutic interventions aimed at inducing cell death. Insights into both the basic and the neoplastic regulation of apoptosis have opened up therapeutic strategies that have already reached the clinic with their full implication yet to be realized. The main objective of this chapter is to review the molecular mechanisms of apoptosis, as well as provide an overview of the existing knowledge of how apoptosis is deregulated in glioblastoma, how it impacts the tumor environment and response to chemotherapy, as well as novel approaches to trigger apoptosis in brain tumors.

Original languageEnglish (US)
Title of host publicationHandbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages13
ISBN (Print)9780128121009
StatePublished - Apr 24 2018
Externally publishedYes


  • Apoptosis
  • Autophagy
  • Glioblastoma
  • Necrosis
  • Senescence

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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