Application of unnatural amino acids to the de novo design of selective antibiotic peptides

Rickey P. Hicks, Amanda L. Russell

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations


Because of their unique mechanism of cytotoxicity against bacteria and other microorganisms, antimicrobial peptides have received a great deal of attention as possible therapeutic agents. Incorporation of unnatural amino acids into the peptide sequences has the potential to improve the organism selectivity and potency of these peptides as well as increase their metabolic stability. This protocol outlines the logic used to selectively incorporate unnatural amino acid into a peptide sequence in an attempt to obtain peptides with increased therapeutic potential as antibiotic agents.

Original languageEnglish (US)
Title of host publicationUnnatural Amino Acids
Subtitle of host publicationMethods and Protocols
EditorsLoredano Pollegioni, Stefano Servi
Number of pages33
StatePublished - 2012
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Antimicrobial peptides
  • De novo
  • Organism selectivity
  • Unnatural amino acids

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'Application of unnatural amino acids to the de novo design of selective antibiotic peptides'. Together they form a unique fingerprint.

Cite this