Aqua mediated synthesis of spirocyclic compounds

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Spirocyclic scaffolds are embedded in many biologically active natural and synthetic compounds. Efforts have been made time to time to develop new and better methodologies for the preparation of spirocyclic compounds. Noteworthy advantages were observed during the course of our study on "in water" synthesis of spirocyclic compounds. The established advantages of using water as a solvent in reactions are: water is the most abundant and available resource on the planet and that many biochemical processes occur in aqueous medium. This review is focused on the use of water in the synthesis of spirocyclic compounds.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalMini-Reviews in Organic Chemistry
Issue number1
StatePublished - 2014
Externally publishedYes


  • Heterocycles
  • Spiro compounds
  • Synthesis
  • Water

ASJC Scopus subject areas

  • Organic Chemistry


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