Arrest chemokines

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

In most organs, leukocyte attachment to the endothelium of blood vessels requires capture and rolling before firm adhesion is initiated by integrin activation and/or redistribution, which can be initiated by immobilized chemokines binding their cognate receptors on rolling cells. Such arrest chemokines are present on the endothelial surface under physiologic or pathologic conditions, necessary, and sufficient to trigger arrest. Although many chemokines can be immobilized and cause arrest of rolling cells in flow chambers, only four have so far been shown to function as arrest chemokines under physiologic conditions, although the actual number could be much higher. Secondary lymphoid tissue chemokine (SLC) (CCL21) on high endothelial venules triggers arrest of rolling lymphocytes, and keratinocyte-derived chemokine (KC) (mouse Gro-α, CXCL1), monocyte chemoattractant protein-1 (MCP-1) (CCL2), and regulated on activation, normal T cell exposed and secreted (RANTES) (CCL5) trigger arrest of rolling monocytes. Remarkably, no arrest chemokine for neutrophils under inflammatory conditions has been found so far.

Original languageEnglish (US)
Pages (from-to)289-295
Number of pages7
JournalMicrocirculation
Volume10
Issue number3-4
DOIs
StatePublished - Jun 2003
Externally publishedYes

Keywords

  • Adhesion molecules
  • Chemokines
  • Integrins
  • Rolling
  • Selections

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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