TY - JOUR
T1 - Aspergillus flavus
T2 - An emerging non-fumigatus Aspergillus species of significance
AU - Krishnan, Suganthini
AU - Manavathu, Elias Kurian
AU - Chandrasekar, Pranatharthi H.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Invasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by Aspergillus fumigatus. The second most frequent (approximately 15-20%) pathogenic species is Aspergillus flavus and to a lesser extent, Aspergillus niger and Aspergillus terreus. Aspergillus flavus has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of A. flavus in the literature. This article reviews the microbiology, toxigenicity and epidemiology of A. flavus as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.
AB - Invasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by Aspergillus fumigatus. The second most frequent (approximately 15-20%) pathogenic species is Aspergillus flavus and to a lesser extent, Aspergillus niger and Aspergillus terreus. Aspergillus flavus has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of A. flavus in the literature. This article reviews the microbiology, toxigenicity and epidemiology of A. flavus as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.
KW - Aflatoxin
KW - Antifungal resistance
KW - Aspergillus
KW - Immunocompromised
KW - Keratitis
KW - Pulmonary aspergillosis
KW - Sinusitis
KW - Triazoles
UR - http://www.scopus.com/inward/record.url?scp=63849275754&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849275754&partnerID=8YFLogxK
U2 - 10.1111/j.1439-0507.2008.01642.x
DO - 10.1111/j.1439-0507.2008.01642.x
M3 - Review article
C2 - 19207851
AN - SCOPUS:63849275754
SN - 0933-7407
VL - 52
SP - 206
EP - 222
JO - Mycoses
JF - Mycoses
IS - 3
ER -
