TY - JOUR
T1 - Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion
AU - Connors, J. E.
AU - DiPiro, J. T.
AU - Hayter, R. G.
AU - Hooker, K. D.
AU - Stanfield, J. A.
AU - Young, T. R.
PY - 1990
Y1 - 1990
N2 - A continuous intravenous infusion was used to assess the tissue penetration of cefazolin (14 subjects) and cefuroxime (15 subjects) in orthopedic surgery patients. Subjects were randomly assigned to receive a continuous intravenous infusion of cefazolin (mean, 178.6 mg/h) or cefuroxime (mean, 330.0 mg/h) at a rate estimated to achieve a target steady-state total concentration of 50 μg/ml in serum. The infusion was initiated 12 to 14 h before surgery, and blood and muscle tissue samples were collected intraoperatively at the times of incision was wound closure. Although there was a significant difference between the free concentrations of cefazolin (at incision, 9.3 μg/ml; at closure, 9.2 μg/ml) and cefuroxime in serum (at incision, 26.9 μg/ml; at closure, 31.8 μg/ml), there was no difference in the total concentrations in muscle at either surgical incision (cefazolin, 6.1 μg/g; cefuroxime, 5.6 μg/g) or wound closure (cefazolin, 7.7 μg/g; cefuroxime, 7.4 μg/g). There was a significant correlation between the pooled free serum and total muscle concentrations for cefazolin (P = 0.001); however, there was no correlation between these variables with the pooleed cefuroxime data (P = 0.403). These findings indicate that the free drug concentration in serum alone is not consistently predictive of the total concentration of cephalosporin in muscle.
AB - A continuous intravenous infusion was used to assess the tissue penetration of cefazolin (14 subjects) and cefuroxime (15 subjects) in orthopedic surgery patients. Subjects were randomly assigned to receive a continuous intravenous infusion of cefazolin (mean, 178.6 mg/h) or cefuroxime (mean, 330.0 mg/h) at a rate estimated to achieve a target steady-state total concentration of 50 μg/ml in serum. The infusion was initiated 12 to 14 h before surgery, and blood and muscle tissue samples were collected intraoperatively at the times of incision was wound closure. Although there was a significant difference between the free concentrations of cefazolin (at incision, 9.3 μg/ml; at closure, 9.2 μg/ml) and cefuroxime in serum (at incision, 26.9 μg/ml; at closure, 31.8 μg/ml), there was no difference in the total concentrations in muscle at either surgical incision (cefazolin, 6.1 μg/g; cefuroxime, 5.6 μg/g) or wound closure (cefazolin, 7.7 μg/g; cefuroxime, 7.4 μg/g). There was a significant correlation between the pooled free serum and total muscle concentrations for cefazolin (P = 0.001); however, there was no correlation between these variables with the pooleed cefuroxime data (P = 0.403). These findings indicate that the free drug concentration in serum alone is not consistently predictive of the total concentration of cephalosporin in muscle.
UR - http://www.scopus.com/inward/record.url?scp=0025332707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025332707&partnerID=8YFLogxK
U2 - 10.1128/AAC.34.6.1128
DO - 10.1128/AAC.34.6.1128
M3 - Article
C2 - 2393271
AN - SCOPUS:0025332707
SN - 0066-4804
VL - 34
SP - 1128
EP - 1131
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 6
ER -