TY - JOUR
T1 - Assignment of the human folate transporter gene to chromosome 21q22.3 by somatic cell hybrid analysis and in situ hybridization
AU - Yang-Feng, Teresa L.
AU - Ma, Yen Ying
AU - Liang, Rong
AU - Prasad, Puttur D
AU - Leibach, Frederick H.
AU - Ganapathy, Vadivel
PY - 1995/5/25
Y1 - 1995/5/25
N2 - We have used the human folate transporter cDNA and a human genomic clone hybridizing to the cDNA to perform chromosomal mapping of the folate transporter gene. Human-rodent somatic cell hybrid analysis using the cDNA as the probe revealed perfect segregation with human chromosome 21. In situ hybridization of the cDNA probe to human metaphase chromosome spreads mapped the folate transporter gene to the distal long arm of chromosome 21, band q22.3. This chromosomal location was confirmed by fluorescence in situ hybridization using the genomic clone.
AB - We have used the human folate transporter cDNA and a human genomic clone hybridizing to the cDNA to perform chromosomal mapping of the folate transporter gene. Human-rodent somatic cell hybrid analysis using the cDNA as the probe revealed perfect segregation with human chromosome 21. In situ hybridization of the cDNA probe to human metaphase chromosome spreads mapped the folate transporter gene to the distal long arm of chromosome 21, band q22.3. This chromosomal location was confirmed by fluorescence in situ hybridization using the genomic clone.
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U2 - 10.1006/bbrc.1995.1739
DO - 10.1006/bbrc.1995.1739
M3 - Article
C2 - 7763259
AN - SCOPUS:0029089831
SN - 0006-291X
VL - 210
SP - 874
EP - 879
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -