Association and linkage analysis of ICD-10 diagnosis for alcoholism

Hemant K. Tiwari, Xiaofeng Zhu, Robert C. Elston, Youyi Shu, Varghese George

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.

Original languageEnglish (US)
Pages (from-to)S343-S347
JournalGenetic Epidemiology
Issue numberSUPPL. 1
StatePublished - 1999
Externally publishedYes


  • Covariates
  • Regression

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)


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