Association and linkage analysis of ICD-10 diagnosis for alcoholism

Hemant K. Tiwari; Xiaofeng Zhu; Robert C. Elston; Youyi Shu; Varghese George

doi:10.1002/gepi.1370170758

Association and linkage analysis of ICD-10 diagnosis for alcoholism

Hemant K. Tiwari, Xiaofeng Zhu, Robert C. Elston, Youyi Shu, Varghese George

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.

Original language	English (US)
Pages (from-to)	S343-S347
Journal	Genetic Epidemiology
Volume	17
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1002/gepi.1370170758
State	Published - 1999
Externally published	Yes

Keywords

Covariates
Regression

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/gepi.1370170758

Cite this

@article{62313d78ed414cacb79ca6b52ee454b6,

title = "Association and linkage analysis of ICD-10 diagnosis for alcoholism",

abstract = "We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.",

keywords = "Covariates, Regression",

author = "Tiwari, {Hemant K.} and Xiaofeng Zhu and Elston, {Robert C.} and Youyi Shu and Varghese George",

year = "1999",

doi = "10.1002/gepi.1370170758",

language = "English (US)",

volume = "17",

pages = "S343--S347",

journal = "Genetic Epidemiology",

issn = "0741-0395",

publisher = "Wiley-Liss Inc.",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Association and linkage analysis of ICD-10 diagnosis for alcoholism

AU - Tiwari, Hemant K.

AU - Zhu, Xiaofeng

AU - Elston, Robert C.

AU - Shu, Youyi

AU - George, Varghese

PY - 1999

Y1 - 1999

N2 - We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.

AB - We analyzed the GAW11 data on alcoholism provided by the Collaborative Study on the Genetics of Alcoholism (COGA) using an extension of a new test of linkage and association for quantitative traits developed by George et al. [1999]. This method determines linkage between marker loci and quantitative traits, when allelic association is present between the trait and marker loci, by regressing the disease trait on the parental transmission of the allele of interest. We found no strong evidence of linkage to any markers. However, we found several markers suggestive of possible linkage that may deserve further investigation.

KW - Covariates

KW - Regression

UR - http://www.scopus.com/inward/record.url?scp=0032758367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032758367&partnerID=8YFLogxK

U2 - 10.1002/gepi.1370170758

DO - 10.1002/gepi.1370170758

M3 - Article

C2 - 10597460

AN - SCOPUS:0032758367

SN - 0741-0395

VL - 17

SP - S343-S347

JO - Genetic Epidemiology

JF - Genetic Epidemiology

IS - SUPPL. 1

ER -

Association and linkage analysis of ICD-10 diagnosis for alcoholism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this