TY - JOUR
T1 - Association between bruxism and symptomatic gastroesophageal reflux disease
T2 - A case-control study
AU - Li, Yuanyuan
AU - Yu, Fan
AU - Niu, Lina
AU - Long, Yong
AU - Tay, Franklin Chi Meng
AU - Chen, Jihua
N1 - Funding Information:
The authors thank the investigators from the Fourth Military Medical University, Xi'an Jiaotong University and the 188th Hospital of the Chinese People's Liberation Army, for their assistance in this case-control study. This work was supported by the National Key Research & Development Program of China (No. 2017YFC0840100 and No. 2017YFC0840109 ), National Natural Science Foundation of China (No. 81720108011 and No. 81470773 ), and Changjiang Scholar Program of Chinese Ministry of Education (No. IRT13051 ). The funding sources had no involvement in the design, conduct or interpretation of the present work or in the decision to submit the manuscript for publication.
Funding Information:
The authors thank the investigators from the Fourth Military Medical University, Xi'an Jiaotong University and the 188th Hospital of the Chinese People's Liberation Army, for their assistance in this case-control study. This work was supported by the National Key Research & Development Program of China (No. 2017YFC0840100 and No. 2017YFC0840109), National Natural Science Foundation of China (No. 81720108011 and No. 81470773), and Changjiang Scholar Program of Chinese Ministry of Education (No. IRT13051). The funding sources had no involvement in the design, conduct or interpretation of the present work or in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/10
Y1 - 2018/10
N2 - Objectives: To examine the relation between bruxism and gastroesophageal reflux disease (GERD) and the contribution of depression, anxiety and impaired sleep quality to that association. Methods: A three-centre case-control study was conducted consisting of 887 consecutive clinically-diagnosed bruxism patients aged 18–75 years and 887 matched controls. Diagnosis of GERD was based on the Montreal definition: moderate/severe symptoms ≥ one day/week or mild symptoms ≥ two days/week. Logistic regression was used to evaluate the association between bruxism and GERD. Mediation analyses were used to test whether the association between bruxism and GERD was mediated by depression, anxiety or impaired sleep quality. Results: Binary logistic regression identified that GERD was associated with bruxism (odds ratio, 6.87; 95% confidence interval (CI), 4.34–10.88). This association was stronger in females (odds ratio, 12.27; 95% CI, 5.81–25.91) than in males (odds ratio, 3.99; 95% CI, 2.17–7.32). Multinomial logistic regression identified that GERD was associated with all types of bruxism (sleep bruxism alone, odds ratio, 6.71, 95% CI, 4.22–10.68; awake bruxism alone, odds ratio, 13.06, 95% CI, 5.32–32.05; overlap of sleep bruxism and awake bruxism, odds ratio, 6.48, 95% CI, 3.05–13.77). Ordinal logistic regression identified that longer GERD duration (> 2 years vs ≤ 2 years) was associated with bruxism frequency (odds ratio, 1.50; 95% CI, 1.10–2.05). Mediation analyses found that the association between bruxism and GERD was partially-mediated through depression, anxiety and impaired sleep quality. Conclusions: Clinically-diagnosed bruxism is associated with symptomatic GERD and is partially-mediated through depression, anxiety and impaired sleep quality. Clinical Significance: Because bruxism is strongly associated with symptomatic GERD and patients with frequent bruxism symptoms tend to suffer from GERD for extensive time-periods, dentists should consider evaluation of GERD status as an elemental part of the medical examination of bruxism, especially severe bruxism.
AB - Objectives: To examine the relation between bruxism and gastroesophageal reflux disease (GERD) and the contribution of depression, anxiety and impaired sleep quality to that association. Methods: A three-centre case-control study was conducted consisting of 887 consecutive clinically-diagnosed bruxism patients aged 18–75 years and 887 matched controls. Diagnosis of GERD was based on the Montreal definition: moderate/severe symptoms ≥ one day/week or mild symptoms ≥ two days/week. Logistic regression was used to evaluate the association between bruxism and GERD. Mediation analyses were used to test whether the association between bruxism and GERD was mediated by depression, anxiety or impaired sleep quality. Results: Binary logistic regression identified that GERD was associated with bruxism (odds ratio, 6.87; 95% confidence interval (CI), 4.34–10.88). This association was stronger in females (odds ratio, 12.27; 95% CI, 5.81–25.91) than in males (odds ratio, 3.99; 95% CI, 2.17–7.32). Multinomial logistic regression identified that GERD was associated with all types of bruxism (sleep bruxism alone, odds ratio, 6.71, 95% CI, 4.22–10.68; awake bruxism alone, odds ratio, 13.06, 95% CI, 5.32–32.05; overlap of sleep bruxism and awake bruxism, odds ratio, 6.48, 95% CI, 3.05–13.77). Ordinal logistic regression identified that longer GERD duration (> 2 years vs ≤ 2 years) was associated with bruxism frequency (odds ratio, 1.50; 95% CI, 1.10–2.05). Mediation analyses found that the association between bruxism and GERD was partially-mediated through depression, anxiety and impaired sleep quality. Conclusions: Clinically-diagnosed bruxism is associated with symptomatic GERD and is partially-mediated through depression, anxiety and impaired sleep quality. Clinical Significance: Because bruxism is strongly associated with symptomatic GERD and patients with frequent bruxism symptoms tend to suffer from GERD for extensive time-periods, dentists should consider evaluation of GERD status as an elemental part of the medical examination of bruxism, especially severe bruxism.
KW - Anxiety
KW - Bruxism
KW - Depression
KW - Gastroesophageal reflux
KW - Risk factors
KW - Sleep
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U2 - 10.1016/j.jdent.2018.07.005
DO - 10.1016/j.jdent.2018.07.005
M3 - Article
C2 - 30017936
AN - SCOPUS:85049797576
SN - 0300-5712
VL - 77
SP - 51
EP - 58
JO - Journal of Dentistry
JF - Journal of Dentistry
ER -