Abstract
A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 267-275 |
| Number of pages | 9 |
| Journal | Genetic Epidemiology |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1987 |
Keywords
- ABO blood group
- low-density lipoprotein cholesterol
- systolic blood pressure
- total cholesterol
ASJC Scopus subject areas
- Epidemiology
- Genetics(clinical)
