TY - JOUR
T1 - Association between Vitamin D levels and allergy-related outcomes vary by race and other factors
AU - Wegienka, Ganesa
AU - Havstad, Suzanne
AU - Zoratti, Edward M.
AU - Kim, Haejin
AU - Ownby, Dennis R.
AU - Johnson, Christine Cole
N1 - Funding Information:
Supported by the National Institutes of Health ( HL113010 , AI051598 , and AI089473 ).
Funding Information:
Disclosure of potential conflict of interest: G. Wegienka, S. Havstad, and H. Kim have received research support from the National Institutes of Health (NIH). E. M. Zoratti has received research support from the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases. D. R. Ownby has received research support from the NIH, is a board member for the Merck Childhood Asthma Network, and has received consultancy fees from Merck. C. Cole Johnson has received research support from the NIH and has received consultancy fees from McNeill (1-day expert panel on acetaminophen and asthma).
Publisher Copyright:
© 2015 American Academy of Allergy, Asthma & Immunology.
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.
AB - Background Allergy-related studies that include biological measurements of Vitamin D preceding well-measured outcomes are needed. Objective We sought to examine the associations between early-life Vitamin D levels and the development of allergy-related outcomes in the racially diverse Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort. Methods 25-HydroxyVitamin D (25[OH]D) levels were measured in stored blood samples from pregnancy, cord blood, and age 2 years. Logistic regression models were used to calculate odds ratios (ORs) with 95% CIs for a 5 ng/mL increase in 25(OH)D levels for the following outcomes at age 2 years: eczema, skin prick tests (SPTs), increased allergen-specific IgE level (≥0.35 IU/mL), and doctor's diagnosis of asthma (3-6 years). Results Prenatal 25(OH)D levels were inversely associated with eczema (OR, 0.85; 95% CI, 0.75-0.96). The association was stronger in white children (white children: OR, 0.79; 95% CI, 0.57-1.09; black children: OR, 0.96; 95% CI, 0.82-1.12), although this was not statistically significant. Cord blood 25(OH)D levels were inversely associated with having 1 or more positive SPT responses and aeroallergen sensitization. Both associations were statistically significant in white children (positive SPT response: OR, 0.50; 95% CI, 0.32-0.80; ≥1 aeroallergen sensitization: OR, 0.50; 95% CI, 0.28-0.92) in contrast with black children (positive SPT response: OR, 0.88; 95% CI, 0.68-1.14; ≥1 aeroallergen sensitization: OR, 0.85; 95% CI, 0.65-1.11). 25(OH)D levels measured concurrently with outcome assessment were inversely associated with aeroallergen sensitization (OR, 0.79; 95% CI, 0.66-0.96) only among black children (white children: OR, 1.21; 95% CI, 0.87-1.69). Conclusions Prenatal and cord blood 25(OH)D levels were associated with some allergy-related outcomes, with a general pattern indicating that children with higher 25(OH)D levels tend to have fewer allergy-related outcomes.
KW - IgE
KW - Vitamin D
KW - allergy
KW - asthma
KW - eczema
KW - racial differences
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U2 - 10.1016/j.jaci.2015.04.017
DO - 10.1016/j.jaci.2015.04.017
M3 - Article
C2 - 26078105
AN - SCOPUS:84956641468
SN - 0091-6749
VL - 136
SP - 1309-1314.e4
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 5
ER -