TY - JOUR
T1 - Association of life-course educational attainment and breast cancer grade in the mend study
AU - Gupta, Anjali
AU - Jones, Kelley
AU - Deveaux, April
AU - Bevel, Malcolm
AU - Salako, Omolola
AU - Daramola, Adetola
AU - Hall, Allison
AU - Alatise, Olusegun
AU - Ogun, Gabriel
AU - Adeniyi, Adewale
AU - Ojo, Akinlolu
AU - Ayandipo, Omobolaji
AU - Olajide, Thomas
AU - Olasehinde, Olalekan
AU - Arowolo, Olukayode
AU - Adisa, Adewale
AU - Afuwape, Oludolapo
AU - Olusanya, Aralola
AU - Adegoke, Aderemi
AU - Tollefsbol, Trygve O.
AU - Arnett, Donna
AU - Newgard, Christopher B.
AU - Akinyemiju, Tomi
N1 - Funding Information:
This research was specifically funded by National Institutes of Health, National Cancer Institute, Fogarty International Center (K01TW010271, T.A.). The views expressed in this paper do not represent the views of the National Institutes of Health, H3Africa Consortium or their funders.
Funding Information:
We thank the many MEND investigators who contributed substantially to the inception and design of the study, and the patients and families who participated in the MEND study for their vital contribution in advancing the science of cancer in Nigeria and globally. We acknowledge the important contribution of the MEND research nurses: Cordelia Ibeneme, Peju Olabanji, Rebecca Israel, Esther Akinwale, Deborah Awodeyi, and Shukurat Oduola. This research was specifically funded by National Institutes of Health, National Cancer Institute, Fogarty International Center (K01TW010271, T.A.). The views expressed in this paper do not represent the views of the National Institutes of Health, H3Africa Consortium or their funders.
Publisher Copyright:
© 2021 The Author(s).
PY - 2021
Y1 - 2021
N2 - Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. Objective: We characterize the association between educational trends across the life-course and BC grade at diagnosis. Methods: Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1–2). Findings: About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant’s education, mother’s education, or life-course education relative to mother. Conclusions: Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.
AB - Background: Nigeria reports the highest age-standardized mortality rate for breast cancer (BC) among African countries and disproportionately high rates of high-grade cancer. Histological grade is a strong predictor of mortality, and evidence suggests that educational attainment influences cancer outcomes. Objective: We characterize the association between educational trends across the life-course and BC grade at diagnosis. Methods: Data on 224 BC patients enrolled in the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Nigerian Women (MEND) study was analyzed. Participant and parental (mother and father) education was categorized as low (primary school or less) or high (secondary school or greater). Accordingly, the educational trend across the life-course was determined for each participant relative to each parent: stable high, increasing, decreasing, or stable low. BC grade was classified as high (grade 3) or low (grades 1–2). Findings: About 34% of participants, 71% of fathers, and 85% of mothers had low education. Approximately one-third of participants were diagnosed with high-grade BC. Participants with low-grade BC were more likely to have highly educated fathers (p = 0.04). After adjusting for age, comorbidities, marital status and mammogram screening, participants with highly educated fathers were 60% less likely to have high-grade BC (aOR 0.41; 95% CI 0.20 to 0.84) compared to those with less-educated fathers. Stable high life-course education relative to father was also associated with a significantly lower likelihood of having high-grade BC (aOR 0.36; 95% CI 0.15 to 0.87) compared to stable low life-course education. No significant associations were observed for the participant’s education, mother’s education, or life-course education relative to mother. Conclusions: Early-life socioeconomic status (SES) may influence BC grade. This deserves further study to inform policies that may be useful in reducing high-grade BC in Nigeria.
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U2 - 10.5334/aogh.3142
DO - 10.5334/aogh.3142
M3 - Article
C2 - 34277361
AN - SCOPUS:85111024101
SN - 0027-2507
VL - 87
JO - Annals of Global Health
JF - Annals of Global Health
IS - 1
M1 - 59
ER -
