Association of the PTPN22/LYP gene with type 1 diabetes

Andrea K. Steck, Si Yang Liu, Kim McFann, Katherine J. Barriga, Sunanda R. Babu, George S. Eisenbarth, Marian J. Rewers, Jin Xiong She

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Objectives: The goal of this study was to verify the association between type 1 diabetes (T1D) and the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene in non-Hispanic whites (NHWs) and Hispanics from Colorado. Subjects and methods: The C1858T single-nucleotide polymorphism within the PTPN22 gene was genotyped in 753 patients with T1D ascertained from the diabetes clinic at the Barbara Davis Center in Denver and 662 control population. Results: Both the PTPN22 CT genotype [odds ratio (OR) = 1.96; p < 0.0001] and TT genotype (OR = 4.41; p = 0.02) were significantly associated with T1D in the NHW population. While the association was stronger in subjects with non-HLA-DR3/4 genotypes than in those with the HLA-DR3/4 genotype, regression analyses did not reveal significant interaction between PTPN22 genotypes and HLA-DR3/4. The strength of the association was similar in males and females, patients diagnosed before and after age 10 yr, and in Hispanics and NHWs. Conclusion: In this study, we confirm that PTPN22 is associated with T1D in the Colorado population.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalPediatric Diabetes
Issue number5
StatePublished - Oct 2006
Externally publishedYes


  • Case
  • Control study
  • HLA
  • LYP
  • PTPN22 gene
  • Type 1 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism


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