Atherosclerosis a chronic inflammatory disease with an autoimmune component

Kouji Kobiyama, Klaus Ley

Research output: Contribution to journalArticlepeer-review

204 Scopus citations


Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries that causes isch-emic heart disease, strokes, and peripheral vascular disease collectively called cardiovascular disease (CVD). Atherosclerosis requires elevated LDL (low-density lipoprotein) cholesterol, which can be controlled by statins and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Both effectively control LDL cholesterol and reduce major adverse cardiovascular events by ≈50%.1

Original languageEnglish (US)
Pages (from-to)1118-1120
Number of pages3
JournalCirculation research
Issue number10
StatePublished - 2018
Externally publishedYes


  • Atherosclerosis
  • Autoimmunity
  • Interleukin-1
  • Peripheral vascular disease
  • Stroke
  • Vaccination

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Atherosclerosis a chronic inflammatory disease with an autoimmune component'. Together they form a unique fingerprint.

Cite this