Atherosclerosis a chronic inflammatory disease with an autoimmune component

Kouji Kobiyama; Klaus Ley

doi:10.1161/CIRCRESAHA.118.313816

Atherosclerosis a chronic inflammatory disease with an autoimmune component

Kouji Kobiyama, Klaus Ley

Research output: Contribution to journal › Article › peer-review

305 Scopus citations

Abstract

Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries that causes isch-emic heart disease, strokes, and peripheral vascular disease collectively called cardiovascular disease (CVD). Atherosclerosis requires elevated LDL (low-density lipoprotein) cholesterol, which can be controlled by statins and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Both effectively control LDL cholesterol and reduce major adverse cardiovascular events by ≈50%.¹

Original language	English (US)
Pages (from-to)	1118-1120
Number of pages	3
Journal	Circulation research
Volume	123
Issue number	10
DOIs	https://doi.org/10.1161/CIRCRESAHA.118.313816
State	Published - 2018
Externally published	Yes

Keywords

Atherosclerosis
Autoimmunity
Interleukin-1
Peripheral vascular disease
Stroke
Vaccination

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/CIRCRESAHA.118.313816

Cite this

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abstract = "Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries that causes isch-emic heart disease, strokes, and peripheral vascular disease collectively called cardiovascular disease (CVD). Atherosclerosis requires elevated LDL (low-density lipoprotein) cholesterol, which can be controlled by statins and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Both effectively control LDL cholesterol and reduce major adverse cardiovascular events by ≈50%.1",

keywords = "Atherosclerosis, Autoimmunity, Interleukin-1, Peripheral vascular disease, Stroke, Vaccination",

author = "Kouji Kobiyama and Klaus Ley",

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year = "2018",

doi = "10.1161/CIRCRESAHA.118.313816",

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AU - Ley, Klaus

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AB - Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries that causes isch-emic heart disease, strokes, and peripheral vascular disease collectively called cardiovascular disease (CVD). Atherosclerosis requires elevated LDL (low-density lipoprotein) cholesterol, which can be controlled by statins and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Both effectively control LDL cholesterol and reduce major adverse cardiovascular events by ≈50%.1

KW - Atherosclerosis

KW - Autoimmunity

KW - Interleukin-1

KW - Peripheral vascular disease

KW - Stroke

KW - Vaccination

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JO - Circulation research

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ER -

Atherosclerosis a chronic inflammatory disease with an autoimmune component

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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