TY - JOUR
T1 - Atopic phenotypes identified with latent class analyses at age 2 years
AU - Havstad, Suzanne
AU - Johnson, Christine Cole
AU - Kim, Haejin
AU - Levin, Albert M.
AU - Zoratti, Edward M.
AU - Joseph, Christine L.M.
AU - Ownby, Dennis R.
AU - Wegienka, Ganesa
N1 - Funding Information:
Disclosure of potential conflict of interest: S. Havstad, A. M. Levin, D. R. Ownby, and G. Wegienka have received research support from the National Institutes of Health (NIH) . C. C. Johnson has received research support from the NIH , has consulted for Sucampo Expert Panel Meeting and McNeil Expert Panel Meeting, and has received payment for lectures from the Aspen Allergy Conference. H. Kim and E. M. Zoratti have received research support from the National Institute of Allergy and Infectious Diseases (NIAID) . C. L. M. Joseph has received research support and travel support from the NIAID .
Funding Information:
Supported by National Institutes of Health grants R01 AI051598 and P01 AI089473 .
PY - 2014/9
Y1 - 2014/9
N2 - Background Atopic sensitization (ie, atopy) is the most commonly reported risk factor for asthma. Recent studies have begun to suggest that atopy, as conventionally defined, might be an umbrella term that obfuscates more specific allergic disease types. Objective We sought to determine whether distinct and meaningful atopic phenotypes exist within a racially diverse birth cohort using 10 allergen-specific serum IgE (sIgE) measurements from children aged 2 years. Methods Using the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort (62% black), we analyzed sIgE data on 10 allergens (Dermatophagoides farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and German cockroach) obtained from 594 children at age 2 years. Conventional atopy was defined as at least 1 sIgE level of 0.35 IU/mL or greater. Results A 4-class solution (latent class model) was the best fit. Class types were labeled "low to no sensitization" (76.9% of sample), "highly sensitized" (2.7%), "milk and egg dominated" (15.3%), and "peanut and inhalant(s)" (5.1%). Almost one third (32.2%) of the low to no sensitization group met the criteria for conventional atopy. The highly sensitized group was significantly associated with a doctor's diagnosis of asthma after age 4 years (odds ratio [OR], 5.3; 95% CI, 1.6-17.4), whereas the milk and egg dominated and peanut and inhalant(s) groups were not (ORs of 1.6 [95% CI, 0.8-3.0] and 1.8 [95% CI, 0.6-4.9], respectively). Children of black race were more likely to be in the 3 multisensitized groups (P =.04). Conclusion Classification by sIgE patterns defined groups whose membership is more strongly associated with atopic dermatitis, wheeze, and asthma compared with conventional atopy.
AB - Background Atopic sensitization (ie, atopy) is the most commonly reported risk factor for asthma. Recent studies have begun to suggest that atopy, as conventionally defined, might be an umbrella term that obfuscates more specific allergic disease types. Objective We sought to determine whether distinct and meaningful atopic phenotypes exist within a racially diverse birth cohort using 10 allergen-specific serum IgE (sIgE) measurements from children aged 2 years. Methods Using the Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort (62% black), we analyzed sIgE data on 10 allergens (Dermatophagoides farinae, dog, cat, timothy grass, ragweed, Alternaria alternata, egg, peanut, milk, and German cockroach) obtained from 594 children at age 2 years. Conventional atopy was defined as at least 1 sIgE level of 0.35 IU/mL or greater. Results A 4-class solution (latent class model) was the best fit. Class types were labeled "low to no sensitization" (76.9% of sample), "highly sensitized" (2.7%), "milk and egg dominated" (15.3%), and "peanut and inhalant(s)" (5.1%). Almost one third (32.2%) of the low to no sensitization group met the criteria for conventional atopy. The highly sensitized group was significantly associated with a doctor's diagnosis of asthma after age 4 years (odds ratio [OR], 5.3; 95% CI, 1.6-17.4), whereas the milk and egg dominated and peanut and inhalant(s) groups were not (ORs of 1.6 [95% CI, 0.8-3.0] and 1.8 [95% CI, 0.6-4.9], respectively). Children of black race were more likely to be in the 3 multisensitized groups (P =.04). Conclusion Classification by sIgE patterns defined groups whose membership is more strongly associated with atopic dermatitis, wheeze, and asthma compared with conventional atopy.
KW - Atopy
KW - birth cohort
KW - latent class analysis
KW - phenotype
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U2 - 10.1016/j.jaci.2014.01.022
DO - 10.1016/j.jaci.2014.01.022
M3 - Article
C2 - 24636082
AN - SCOPUS:84906944572
SN - 0091-6749
VL - 134
SP - 722-727.e2
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 3
ER -