Atorvastatin prevents endothelial dysfunction in high glucose condition through Skp2-mediated degradation of FOXO1 and ICAM-1

Keyphrases

• 3-hydroxy-3-methylglutaryl-coenzyme A 8%
• Adhesion Test 8%
• Atorvastatin 100%
• Co-immunoprecipitation (co-IP) 8%
• Diabetes 16%
• Diabetic Endothelial Dysfunction 8%
• Endothelial Cells 16%
• Endothelial Dysfunction 100%
• Endothelial Function 8%
• Forkhead Box O1 (FOXO1) 100%
• High Glucose 100%
• Intercellular Adhesion molecule-1 (ICAM-1) 100%
• Knockdown 8%
• Monocyte Adhesion 16%
• Protease Inhibitors 8%
• Protective Behavior 8%
• Protective Effect 8%
• Protective Mechanism 8%
• Protein Level 8%
• Reductase Inhibitors 8%
• S-phase Kinase-associated Protein 2 (Skp2) 100%
• Statins 8%
• Ubiquitination 33%

Biochemistry, Genetics and Molecular Biology

• Atorvastatin 100%
• FOXO1 100%
• HMG-CoA 8%
• ICAM-1 100%
• Immunoprecipitation 8%
• Kinase 100%
• Monocyte 16%
• Oxidoreductase 8%
• Phosphotransferase 100%
• Protease Inhibitor 8%
• Reductase 8%
• S Phase 100%
• Statin 8%
• Transcription Factor FKHR 8%
• Ubiquitination 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Atorvastatin 100%
• Endothelial Dysfunction 100%
• HMG-CoA 8%
• Immunoprecipitation 8%
• Intercellular Adhesion Molecule 1 100%
• Oxidoreductase 8%
• Proteinase Inhibitor 8%
• S Phase Kinase Associated Protein 2 100%
• Transcription Factor FKHR 8%