TY - JOUR
T1 - Atrial natriuretic factor and blood pressure control
T2 - Role of sodium and aldosterone
AU - Gaillard, C. A.
AU - Mizelle, H. L.
AU - Montani, J. P.
AU - Brands, M. W.
AU - Hildebrandt, D. A.
AU - Hall, J. E.
PY - 1990
Y1 - 1990
N2 - This study examined the long-term actions of atrial natriuretic factor (ANF), at physiological levels, on renal function and mean arterial pressure (MAP) and the importance of Na intake and the renin-angiotensin-aldosterone system in modulating those effects. After a control period, ANF was infused intravenously at a rate of 10 ng·kg-1·min-1 for 7 days, followed by 7 days of 20 ng·kg-1·min-1 and 7 days of recovery. After 7 days of ANF at 10 ng·kg-1·min-1, MAP decreased from 87 ± 3 to 80 ± 2 mmHg in normal dogs on low sodium intake (LS, 7 meq Na/day) and from 89 ± 2 to 79 ± 2 mmHg in adrenalectomized dogs (ADX, 7 meq Na/day) given constant mineralocorticoid replacement. In both groups, no significant change in glomerular filtration rate (GFR) was observed, although sodium excretion increased transiently. ANF failed to cause significant changes in MAP, GFR, or sodium excretion in normal dogs on high sodium intake (HS, 269 meq Na/day). In LS and HS no long-term effects of ANF on plasma renin activity (PRA) and aldosterone were observed. In ADX, as expected, no change in aldosterone was observed. Thus, in normal and adrenalectomized dogs on LS, chronic ANF infusion caused sustained reductions in MAP. HS markedly attenuated the hypotensive effect of ANF. Our data suggest that the long-term effect of ANF is salt sensitive but that decreases in PRA and aldosterone are not essential for the long-term hypotensive effect of ANF.
AB - This study examined the long-term actions of atrial natriuretic factor (ANF), at physiological levels, on renal function and mean arterial pressure (MAP) and the importance of Na intake and the renin-angiotensin-aldosterone system in modulating those effects. After a control period, ANF was infused intravenously at a rate of 10 ng·kg-1·min-1 for 7 days, followed by 7 days of 20 ng·kg-1·min-1 and 7 days of recovery. After 7 days of ANF at 10 ng·kg-1·min-1, MAP decreased from 87 ± 3 to 80 ± 2 mmHg in normal dogs on low sodium intake (LS, 7 meq Na/day) and from 89 ± 2 to 79 ± 2 mmHg in adrenalectomized dogs (ADX, 7 meq Na/day) given constant mineralocorticoid replacement. In both groups, no significant change in glomerular filtration rate (GFR) was observed, although sodium excretion increased transiently. ANF failed to cause significant changes in MAP, GFR, or sodium excretion in normal dogs on high sodium intake (HS, 269 meq Na/day). In LS and HS no long-term effects of ANF on plasma renin activity (PRA) and aldosterone were observed. In ADX, as expected, no change in aldosterone was observed. Thus, in normal and adrenalectomized dogs on LS, chronic ANF infusion caused sustained reductions in MAP. HS markedly attenuated the hypotensive effect of ANF. Our data suggest that the long-term effect of ANF is salt sensitive but that decreases in PRA and aldosterone are not essential for the long-term hypotensive effect of ANF.
KW - Adrenalectomy
KW - Atrial natriuretic peptide
KW - Renal function
KW - Renal hemodynamics
KW - Renin-angiotensin system
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U2 - 10.1152/ajpregu.1990.259.5.r973
DO - 10.1152/ajpregu.1990.259.5.r973
M3 - Article
C2 - 2146893
AN - SCOPUS:0025011687
SN - 0002-9513
VL - 259
SP - R973-R980
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 5 28-5
ER -