Atrial natriuretic factor and blood pressure control: Role of sodium and aldosterone

C. A. Gaillard, H. L. Mizelle, J. P. Montani, M. W. Brands, D. A. Hildebrandt, J. E. Hall

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


This study examined the long-term actions of atrial natriuretic factor (ANF), at physiological levels, on renal function and mean arterial pressure (MAP) and the importance of Na intake and the renin-angiotensin-aldosterone system in modulating those effects. After a control period, ANF was infused intravenously at a rate of 10 ng·kg-1·min-1 for 7 days, followed by 7 days of 20 ng·kg-1·min-1 and 7 days of recovery. After 7 days of ANF at 10 ng·kg-1·min-1, MAP decreased from 87 ± 3 to 80 ± 2 mmHg in normal dogs on low sodium intake (LS, 7 meq Na/day) and from 89 ± 2 to 79 ± 2 mmHg in adrenalectomized dogs (ADX, 7 meq Na/day) given constant mineralocorticoid replacement. In both groups, no significant change in glomerular filtration rate (GFR) was observed, although sodium excretion increased transiently. ANF failed to cause significant changes in MAP, GFR, or sodium excretion in normal dogs on high sodium intake (HS, 269 meq Na/day). In LS and HS no long-term effects of ANF on plasma renin activity (PRA) and aldosterone were observed. In ADX, as expected, no change in aldosterone was observed. Thus, in normal and adrenalectomized dogs on LS, chronic ANF infusion caused sustained reductions in MAP. HS markedly attenuated the hypotensive effect of ANF. Our data suggest that the long-term effect of ANF is salt sensitive but that decreases in PRA and aldosterone are not essential for the long-term hypotensive effect of ANF.

Original languageEnglish (US)
Pages (from-to)R973-R980
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 28-5
StatePublished - 1990
Externally publishedYes


  • Adrenalectomy
  • Atrial natriuretic peptide
  • Renal function
  • Renal hemodynamics
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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