Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

R. T. McCarthy, C. M. Isales, W. B. Bollag, H. Rasmussen, P. Q. Barrett

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium influx through voltage-dependent calcium channels. Because two types of calcium channels have been previously described in bovine glomerulosa cells (T- and L-type), the patch-clamp technique was used to evaluate the effect of ANP on each voltage-dependent calcium channel type. ANP was found to differentially modulate these two channel types, stimulating L-current while inhibiting T-current. Inhibition of T-current resulted from a shift in the voltage dependence of inactivation to more negative potentials within the physiological range. These results indicate that the ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of the calcium current through T-type channels.

Original languageEnglish (US)
Pages (from-to)F473-F478
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Issue number3 27-3
StatePublished - 1990
Externally publishedYes


  • aldosterone secretion

ASJC Scopus subject areas

  • Physiology


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