Abstract
The pathogenic mechanisms underlying Batten disease are unclear. Patients uniformly possess autoantibodies against glutamic acid decarboxylase (GAD) that are predominantly reactive with a region of GAD (amino acids 1 to 20) distinct from subjects with autoimmune type 1 diabetes or stiff-person syndrome. Batten patients did not possess autoantibodies against other type 1 diabetes-associated autoantigens and human leukocyte antigen genotypes revealed no specific associations with this disease.
Original language | English (US) |
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Pages (from-to) | 743-745 |
Number of pages | 3 |
Journal | Neurology |
Volume | 64 |
Issue number | 4 |
DOIs | |
State | Published - Feb 22 2005 |
ASJC Scopus subject areas
- Clinical Neurology