Autophagy and p62 in cardiac protein quality control

Huabo Su; Xuejun Wang

doi:10.4161/auto.7.11.17339

Autophagy and p62 in cardiac protein quality control

Huabo Su, Xuejun Wang

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.

Original language	English (US)
Pages (from-to)	1382-1383
Number of pages	2
Journal	Autophagy
Volume	7
Issue number	11
DOIs	https://doi.org/10.4161/auto.7.11.17339
State	Published - Nov 2011
Externally published	Yes

Keywords

Autophagy
Cardiomyocytes
Desmin-related cardiomyopathy
Protein aggregation
p62

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.7.11.17339

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AB - This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.

KW - Autophagy

KW - Cardiomyocytes

KW - Desmin-related cardiomyopathy

KW - Protein aggregation

KW - p62

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Autophagy and p62 in cardiac protein quality control

Abstract

Keywords

ASJC Scopus subject areas

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