TY - JOUR
T1 - Autophagy in neurodegenerative disorders
T2 - Pathogenic roles and therapeutic implications
AU - Banerjee, Rebecca
AU - Beal, M. Flint
AU - Thomas, Bobby
N1 - Funding Information:
This work was supported by National Institutes of Health grants NS060885, NS062165 (B.T.) and ES017295 (M.F.B.), and grants from the Michael J. Fox Foundation for Parkinson's disease (B.T and M.F.B) and the Department of Defense (M.F.B.).
PY - 2010/12
Y1 - 2010/12
N2 - Autophagy is a highly conserved intracellular pathway involved in the elimination of proteins and organelles by lysosomes. Known originally as an adaptive response to nutrient deprivation in mitotic cells, autophagy is now recognized as an arbiter of neuronal survival and death decisions in neurodegenerative diseases. Studies using postmortem human tissue, genetic and toxin-induced animal and cellular models indicate that many of the etiological factors associated with neurodegenerative disorders can perturb the autophagy process. Emerging data support the view that dysregulation of autophagy might play a critical role in the pathogenesis of neurodegenerative disorders. In this review, we highlight the pathophysiological roles of autophagy and its potential therapeutic implications in debilitating neurodegenerative disorders, including amyotrophic lateral sclerosis and Alzheimer's, Parkinson's and Huntington's diseases.
AB - Autophagy is a highly conserved intracellular pathway involved in the elimination of proteins and organelles by lysosomes. Known originally as an adaptive response to nutrient deprivation in mitotic cells, autophagy is now recognized as an arbiter of neuronal survival and death decisions in neurodegenerative diseases. Studies using postmortem human tissue, genetic and toxin-induced animal and cellular models indicate that many of the etiological factors associated with neurodegenerative disorders can perturb the autophagy process. Emerging data support the view that dysregulation of autophagy might play a critical role in the pathogenesis of neurodegenerative disorders. In this review, we highlight the pathophysiological roles of autophagy and its potential therapeutic implications in debilitating neurodegenerative disorders, including amyotrophic lateral sclerosis and Alzheimer's, Parkinson's and Huntington's diseases.
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U2 - 10.1016/j.tins.2010.09.001
DO - 10.1016/j.tins.2010.09.001
M3 - Review article
C2 - 20947179
AN - SCOPUS:78149471570
SN - 0166-2236
VL - 33
SP - 541
EP - 549
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 12
ER -