Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-Months randomized clinical trial

Alex N. Haas, Gabriel D. De Castro, Tatiana Moreno, Cristiano Susin, Jasim M. Albandar, Rui V. Oppermann, Cassiano K. Rösing

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Aim: To assess the effect of systemic azithromycin as a supplement to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP). Material and Methods: Twenty-four individuals (13-26 years old) underwent a plaque control program, and then were treated with SRP. Subjects were assigned randomly into two groups; the test group used 500 mg azithromycin once a day for 3 days, whereas the control group used a placebo. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. The periodontal status at baseline and 12 months was compared using the Wald test, and adjusting for the effect of clustering of teeth within subjects. Results: There were no significant differences in visible plaque, gingival bleeding, and supragingival calculus between groups throughout the study. Periodontal probing depth (PPD) and clinical attachment level improved significantly from baseline to 12 months in both groups, with the test group showing significantly more reduction in mean PPD compared with controls (2.88 mm versus 1.85 mm, respectively, p=0.025). Subjects administering azithromycin showed a higher percentage of teeth with attachment gain ≥1 mm (81.34 versus 63.63, p=0.037), whereas the controls had higher percentage of teeth with attachment loss ≥1 mm (11.57 versus 2.24, p=0.015). Conclusions: The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.

Original languageEnglish (US)
Pages (from-to)696-704
Number of pages9
JournalJournal of Clinical Periodontology
Issue number8
StatePublished - Aug 2008
Externally publishedYes


  • Adolescents/young-adults
  • Antibiotics
  • Azithromycin
  • Periodontal disease
  • Randomized controlled trial

ASJC Scopus subject areas

  • Periodontics


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