Beneficial role of phytochemicals on oxidative stress and age-related diseases

Cinzia Forni, Francesco Facchiano, Manuela Bartoli, Stefano Pieretti, Antonio Facchiano, Daniela D'Arcangelo, Sandro Norelli, Giorgia Valle, Roberto Nisini, Simone Beninati, Claudio Tabolacci, Ravirajsinh N. Jadeja

Research output: Contribution to journalReview articlepeer-review

228 Scopus citations


Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs. & copy; 2019 Cinzia Forni et al.

Original languageEnglish (US)
Article number8748253
JournalBioMed Research International
StatePublished - 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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