TY - JOUR
T1 - Beyond antibody-mediated rejection
T2 - Hyperacute lung rejection as a paradigm for dysregulated inflammation
AU - Nguyen, Bao H.
AU - Zwets, Egon
AU - Schroeder, Carsten
AU - Pierson, Richard N.
AU - Azimzadeh, Agnes M.
PY - 2005/6
Y1 - 2005/6
N2 - The use of animal organs for transplantation in humans is seen as a potential solution to the short supply of human donor organs available for clinical transplantation. However, to develop this therapeutic option as clinical reality will require surmounting formidable obstacles. The primary immunologic barrier to pig-to-human xenotransplantation is hyperacute rejection (HAR), a phenomenon previously characterized as resulting from antibody binding and complement activation. This article will first review recent progress in the development of specific strategies to overcome hyperacute lung rejection (HALR), through production of genetically engineered pig organs, modification of the host innate immunity and control of antibody and complement. Additional therapeutic targets identified in HALR are reviewed, with particular emphasis on recent studies describing a critical role for the coagulation cascade in HAR.
AB - The use of animal organs for transplantation in humans is seen as a potential solution to the short supply of human donor organs available for clinical transplantation. However, to develop this therapeutic option as clinical reality will require surmounting formidable obstacles. The primary immunologic barrier to pig-to-human xenotransplantation is hyperacute rejection (HAR), a phenomenon previously characterized as resulting from antibody binding and complement activation. This article will first review recent progress in the development of specific strategies to overcome hyperacute lung rejection (HALR), through production of genetically engineered pig organs, modification of the host innate immunity and control of antibody and complement. Additional therapeutic targets identified in HALR are reviewed, with particular emphasis on recent studies describing a critical role for the coagulation cascade in HAR.
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U2 - 10.2174/1568006054064753
DO - 10.2174/1568006054064753
M3 - Review article
C2 - 15975038
AN - SCOPUS:21044452660
SN - 1568-0061
VL - 5
SP - 255
EP - 269
JO - Current Drug Targets - Cardiovascular and Haematological Disorders
JF - Current Drug Targets - Cardiovascular and Haematological Disorders
IS - 3
ER -