TY - JOUR
T1 - Beyond calorie restriction
T2 - aging as a biological target for nutrient therapies
AU - Austad, Steven N.
AU - Hoffman, Jessica M.
N1 - Funding Information:
Our research is funded by N.I.H. grants R01 AG057434 , R21 AG058811 , P30 AG050886 (S.N.A.) and K99AG059920 (J.M.H.) and the Glenn Foundation for Medical Research .
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Arguably, the most important discovery in the biology of aging to date was that simply reducing food intake extended life and improved many aspects of health in a diversity of animal species. The conventional wisdom that emerged from first 50 years of rodent food restriction studies included (1) that the longevity impact of restriction was greater the longer restriction was imposed, and (2) that restricting calories rather than any specific macronutrient was critical to its health and longevity benefits. However these assumptions began to crumble as more and more restriction research was performed on other species besides laboratory rodents. Recent investigations of flies, rodents, monkeys, and increasingly humans, has begun to parse how calorie restriction, protein restriction, intermittent fasting, and the temporal pattern of eating all impact the health benefits of food restriction. Fly research continues to inform, as it has repeatedly shown that genotype, age, sex, duration, and tempo restriction all affect the health impact. Ultimately, optimizing human diets will require a personalized approach using omics approaches.
AB - Arguably, the most important discovery in the biology of aging to date was that simply reducing food intake extended life and improved many aspects of health in a diversity of animal species. The conventional wisdom that emerged from first 50 years of rodent food restriction studies included (1) that the longevity impact of restriction was greater the longer restriction was imposed, and (2) that restricting calories rather than any specific macronutrient was critical to its health and longevity benefits. However these assumptions began to crumble as more and more restriction research was performed on other species besides laboratory rodents. Recent investigations of flies, rodents, monkeys, and increasingly humans, has begun to parse how calorie restriction, protein restriction, intermittent fasting, and the temporal pattern of eating all impact the health benefits of food restriction. Fly research continues to inform, as it has repeatedly shown that genotype, age, sex, duration, and tempo restriction all affect the health impact. Ultimately, optimizing human diets will require a personalized approach using omics approaches.
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U2 - 10.1016/j.copbio.2020.11.008
DO - 10.1016/j.copbio.2020.11.008
M3 - Review article
C2 - 33360494
AN - SCOPUS:85098216448
SN - 0958-1669
VL - 70
SP - 56
EP - 60
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -