Bicyclic 6-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

Siva S. Panda; Jason Alexander Carr

doi:10.1016/B978-0-12-409547-2.14944-3

Bicyclic 6-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

Siva S. Panda, Jason Alexander Carr

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The reports of bicyclic 6-6 systems with one bridgehead nitrogen atom and four extra heteroatoms are sparse in the literature. Since the last review,1 only twelve new bicyclic 6-6 derivatives 23-34 have been reported. 2-11 In all cases, synthesis of the new structures started from substituted 4-amino-3-thioxo-1,2,4-triazin-5-ones. In most cases, NMR spectroscopy, mass spectrometry and IR spectroscopy were used to characterize the compounds. Compounds 23, 26 and 27 show good biological activity.

Original language	English (US)
Title of host publication	Comprehensive Heterocyclic Chemistry IV
Publisher	Elsevier
Pages	297-304
Number of pages	8
ISBN (Electronic)	9780128186565
ISBN (Print)	9780128186558
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.14944-3
State	Published - Jan 1 2021

Keywords

1,2,4-Triazin-5-one
Antifungal
Antioxidant
Antitumor
Bicyclic 6-6 systems
Bridgehead nitrogen atom
Heterocycles
IR spectroscopy
NMR spectroscopy
X-ray crystallography

ASJC Scopus subject areas

General Chemistry

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10.1016/B978-0-12-409547-2.14944-3

Cite this

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abstract = "The reports of bicyclic 6-6 systems with one bridgehead nitrogen atom and four extra heteroatoms are sparse in the literature. Since the last review,1 only twelve new bicyclic 6-6 derivatives 23-34 have been reported. 2-11 In all cases, synthesis of the new structures started from substituted 4-amino-3-thioxo-1,2,4-triazin-5-ones. In most cases, NMR spectroscopy, mass spectrometry and IR spectroscopy were used to characterize the compounds. Compounds 23, 26 and 27 show good biological activity.",

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AB - The reports of bicyclic 6-6 systems with one bridgehead nitrogen atom and four extra heteroatoms are sparse in the literature. Since the last review,1 only twelve new bicyclic 6-6 derivatives 23-34 have been reported. 2-11 In all cases, synthesis of the new structures started from substituted 4-amino-3-thioxo-1,2,4-triazin-5-ones. In most cases, NMR spectroscopy, mass spectrometry and IR spectroscopy were used to characterize the compounds. Compounds 23, 26 and 27 show good biological activity.

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KW - Antioxidant

KW - Antitumor

KW - Bicyclic 6-6 systems

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KW - IR spectroscopy

KW - NMR spectroscopy

KW - X-ray crystallography

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Bicyclic 6-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Four Extra Heteroatoms 2:2

Abstract

Keywords

ASJC Scopus subject areas

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