Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus

Thomas Straube; Volker Korz; Julietta U. Frey

doi:10.1016/S0304-3940(03)00349-5

Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus

Thomas Straube, Volker Korz, Julietta U. Frey

Neurology

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f=200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to 1 min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and -enhancing factors may be relevant for the modulation of memory formation by novelty.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience Letters
Volume	344
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00349-5
State	Published - Jun 19 2003

Keywords

Dentate gyrus
LTP-reinforcement
LTP-reversal
Late-LTP
Learning
Long-term potentiation
Memory formation
Novelty

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(03)00349-5

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title = "Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus",

abstract = "Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f=200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to 1 min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and -enhancing factors may be relevant for the modulation of memory formation by novelty.",

keywords = "Dentate gyrus, LTP-reinforcement, LTP-reversal, Late-LTP, Learning, Long-term potentiation, Memory formation, Novelty",

author = "Thomas Straube and Volker Korz and Frey, {Julietta U.}",

note = "Funding Information: We are grateful to Professor Dr D. v. Holst and Dr V. Stefanski for analysing the blood samples in the Animal Department of Physiology, Bayreuth, Germany. We thank Dr D. Balschun and Dr S. Leutgeb for their comments on this work. This work was supported by funds by the EU Framework V {\textquoteleft}NAPPY{\textquoteright} to JUF.",

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PY - 2003/6/19

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N2 - Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f=200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to 1 min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and -enhancing factors may be relevant for the modulation of memory formation by novelty.

AB - Previous studies have shown that exploration of a novel environment reverses hippocampal long-term potentiation (LTP). Here we demonstrate a bidirectional modulation of LTP measured in the dentate gyrus of freely moving rats by means of novelty exploration. A transient form of LTP lasting about 6 h was induced in perforant path-granular cell-synapses by a weak tetanization protocol (three bursts of 15 pulses at f=200 Hz). LTP was reversed when non-restricted exploration of a novel environment started 2 min after LTP induction. In contrast, using the same interval and limiting the exploration duration to 1 min led to LTP-prolongation. Furthermore, LTP-reinforcement was also obtained when a not-restricted exploration started within 2 min before tetanization. The observed interplay of LTP-impairing and -enhancing factors may be relevant for the modulation of memory formation by novelty.

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Bidirectional modulation of long-term potentiation by novelty-exploration in rat dentate gyrus

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Keywords

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