TY - JOUR
T1 - Bifocal juvenile papillomatosis as a marker of breast cancer
T2 - A case report and review of the literature
AU - Wang, Tong
AU - Li, Ya Qing
AU - Liu, Hong
AU - Fu, Xi Lin
AU - Tang, Shou Ching
N1 - Publisher Copyright:
© Spandidos Publications 2014. All rights reserved.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Juvenile papillomatosis (JP), also termed Swiss cheese disease, is a rare and benign type of proliferative breast tumor that is specifically observed in children and adolescents. The majority of JP patients are Caucasian and exhibit a single breast mass. The current report presents an unusual case of bifocal JP in an 11-year-old Chinese female. The patient presented with a slow-growing palpable mass in the upper outer quadrant of the left breast. Ultrasonography identified a further impalpable lesion in the lower outer quadrant of the ipsilateral breast. The preoperative clinical diagnosis of the two masses was fibroadenoma, however, following complete excision of the two tumors, histopathology revealed JP. Furthermore, the patient had a family history of breast cancer. The current report describes a review of the literature regarding the presentation, pathology, diagnosis, and treatment of JP and its association with breast carcinoma. In the current case, JP was associated with an increased risk of breast cancer in the patient, as well as the patient's elder female relatives; therefore, a more thorough medical follow-up may prove prudent for those individuals with a high risk of developing breast cancer.
AB - Juvenile papillomatosis (JP), also termed Swiss cheese disease, is a rare and benign type of proliferative breast tumor that is specifically observed in children and adolescents. The majority of JP patients are Caucasian and exhibit a single breast mass. The current report presents an unusual case of bifocal JP in an 11-year-old Chinese female. The patient presented with a slow-growing palpable mass in the upper outer quadrant of the left breast. Ultrasonography identified a further impalpable lesion in the lower outer quadrant of the ipsilateral breast. The preoperative clinical diagnosis of the two masses was fibroadenoma, however, following complete excision of the two tumors, histopathology revealed JP. Furthermore, the patient had a family history of breast cancer. The current report describes a review of the literature regarding the presentation, pathology, diagnosis, and treatment of JP and its association with breast carcinoma. In the current case, JP was associated with an increased risk of breast cancer in the patient, as well as the patient's elder female relatives; therefore, a more thorough medical follow-up may prove prudent for those individuals with a high risk of developing breast cancer.
KW - Breast cancer risk
KW - Diagnosis and treatment
KW - Juvenile papillomatosis
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U2 - 10.3892/ol.2014.2600
DO - 10.3892/ol.2014.2600
M3 - Article
AN - SCOPUS:84908046575
SN - 1792-1074
VL - 8
SP - 2587
EP - 2590
JO - Oncology Letters
JF - Oncology Letters
IS - 6
ER -