Bilateral Acute Retinal Necrosis: Clinical and Ultrastructural Study

Harvey W. Topilow, Julian J. Nussbaum, H. Mac Kenzie Freeman, G. Richard Dickersin, Wanda Szyfelbein

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In a 28-year-old man with bilateral acute retinal necrosis, a severe, bilateral panuveitis, necrotizing retinitis, and retinal vasculitis developed. Severe vitreous traction on atrophic retina resulted in bilateral giant retinal tears with an inoperable retinal detachment in the right eye. A retinal detachment developed in the left eye that was reattached after a pars plana vitrectomy and two scleral buckling procedures, but ultimately became inoperable. Large numbers of lymphocytes in the vitreous aspirate and depressed serum complement levels may indicate that an immune mechanism was involved in the necrotizing retinitis. We present the first electron microscopic evidence, to our knowledge, that preretinal membranes occurring in rhegmatogenous retinal detachment due to bilateral acute retinal necrosis arise from retinal pigment epithelium.

Original languageEnglish (US)
Pages (from-to)1901-1908
Number of pages8
JournalArchives of Ophthalmology
Issue number12
StatePublished - Dec 1982

ASJC Scopus subject areas

  • Ophthalmology


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