Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin

Yaakov Naparstek; Arie Ben‐Yehuda; Michael P. Madaio; Ruth Bar‐Tana; Lucy Schuger; Galina Pizov; Zvi Neeman; Irun R. Cohen

doi:10.1002/art.1780331013

Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin

Yaakov Naparstek, Arie Ben‐Yehuda, Michael P. Madaio, Ruth Bar‐Tana, Lucy Schuger, Galina Pizov, Zvi Neeman, Irun R. Cohen

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

Original language	English (US)
Pages (from-to)	1554-1559
Number of pages	6
Journal	Arthritis & Rheumatism
Volume	33
Issue number	10
DOIs	https://doi.org/10.1002/art.1780331013
State	Published - Oct 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology
Pharmacology (medical)

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abstract = "Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.",

author = "Yaakov Naparstek and Arie Ben‐Yehuda and Madaio, {Michael P.} and Ruth Bar‐Tana and Lucy Schuger and Galina Pizov and Zvi Neeman and Cohen, {Irun R.}",

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AU - Naparstek, Yaakov

AU - Ben‐Yehuda, Arie

AU - Madaio, Michael P.

AU - Bar‐Tana, Ruth

AU - Schuger, Lucy

AU - Pizov, Galina

AU - Neeman, Zvi

AU - Cohen, Irun R.

PY - 1990/10

Y1 - 1990/10

N2 - Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

AB - Heparin was found to inhibit the DNA binding of antibodies eluted from kidneys of both humans and MRL‐lpr/lpr mice with systemic lupus erythematosus. Treatment of MRL‐lpr/lpr mice with low doses of heparin significantly inhibited renal damage. These results suggest that low‐dose heparin might be useful in preventing renal damage in patients with lupus nephritis.

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Binding of anti‐DNA antibodies and inhibition of glomerulonephritis in MRL‐lpr/lpr mice by heparin

Abstract

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