TY - JOUR
T1 - Biochemical Characteristics of Microbial Enzymes and Their Significance from Industrial Perspectives
AU - Thapa, Santosh
AU - Li, Hui
AU - OHair, Joshua
AU - Bhatti, Sarabjit
AU - Chen, Fur Chi
AU - Nasr, Kamal Al
AU - Johnson, Terrance
AU - Zhou, Suping
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Microbes are ubiquitously distributed in nature and are a critical part of the holobiont fitness. They are perceived as the most potential biochemical reservoir of inordinately diverse and multi-functional enzymes. The robust nature of the microbial enzymes with thermostability, pH stability and multi-functionality make them potential candidates for the efficient biotechnological processes under diverse physio-chemical conditions. The need for sustainable solutions to various environmental challenges has further surged the demand for industrial enzymes. Fueled by the recent advent of recombinant DNA technology, genetic engineering, and high-throughput sequencing and omics techniques, numerous microbial enzymes have been developed and further exploited for various industrial and therapeutic applications. Most of the hydrolytic enzymes (protease being the dominant hydrolytic enzyme) have broad range of industrial uses such as food and feed processing, polymer synthesis, production of pharmaceuticals, manufactures of detergents, paper and textiles, and bio-fuel refinery. In this review article, after a short overview of microbial enzymes, an approach has been made to highlight and discuss their potential relevance in biotechnological applications and industrial bio-processes, significant biochemical characteristics of the microbial enzymes, and various tools that are revitalizing the novel enzymes discovery.
AB - Microbes are ubiquitously distributed in nature and are a critical part of the holobiont fitness. They are perceived as the most potential biochemical reservoir of inordinately diverse and multi-functional enzymes. The robust nature of the microbial enzymes with thermostability, pH stability and multi-functionality make them potential candidates for the efficient biotechnological processes under diverse physio-chemical conditions. The need for sustainable solutions to various environmental challenges has further surged the demand for industrial enzymes. Fueled by the recent advent of recombinant DNA technology, genetic engineering, and high-throughput sequencing and omics techniques, numerous microbial enzymes have been developed and further exploited for various industrial and therapeutic applications. Most of the hydrolytic enzymes (protease being the dominant hydrolytic enzyme) have broad range of industrial uses such as food and feed processing, polymer synthesis, production of pharmaceuticals, manufactures of detergents, paper and textiles, and bio-fuel refinery. In this review article, after a short overview of microbial enzymes, an approach has been made to highlight and discuss their potential relevance in biotechnological applications and industrial bio-processes, significant biochemical characteristics of the microbial enzymes, and various tools that are revitalizing the novel enzymes discovery.
KW - Biochemical characteristics
KW - Industrial applications
KW - Microbial enzymes
KW - Recombinant DNA technology
UR - http://www.scopus.com/inward/record.url?scp=85067002129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067002129&partnerID=8YFLogxK
U2 - 10.1007/s12033-019-00187-1
DO - 10.1007/s12033-019-00187-1
M3 - Review article
C2 - 31168761
AN - SCOPUS:85067002129
SN - 1073-6085
VL - 61
SP - 579
EP - 601
JO - Molecular Biotechnology
JF - Molecular Biotechnology
IS - 8
ER -