TY - JOUR
T1 - Biological activities and potential oral applications of N-acetylcysteine
T2 - Progress and prospects
AU - Pei, Yanping
AU - Liu, Huan
AU - Yang, Yi
AU - Yang, Yanwei
AU - Jiao, Yang
AU - Tay, Franklin Chi Meng
AU - Chen, Jihua
N1 - Funding Information:
This work was supported by Grant nos. 81600919 (principal investigator Yi Yang) and 81720108011 (principal investigator Jihua Chen) from the National Nature Science Foundation of China, Beijing Nova Program (Grant no. xx2018097) (principal investigator Yi Yang), and Program no. IRT13051 from the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).
Publisher Copyright:
Copyright © 2018 Yanping Pei et al.
PY - 2018
Y1 - 2018
N2 - N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.
AB - N-Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been used for several decades in clinical therapeutic practices as a mucolytic agent and for the treatment of disorders associated with GSH deficiency. Other therapeutic activities of NAC include inhibition of inflammation/NF-κB signaling and expression of proinflammatory cytokines. N-Acetylcysteine is also a nonantibiotic compound possessing antimicrobial property and exerts anticarcinogenic and antimutagenic effects against certain types of cancer. Recently, studies describing potentially important biological and pharmacological activities of NAC have stimulated interests in using NAC-based therapeutics for oral health care. The present review focused on the biological activities of NAC and its potential oral applications. The potential side effects of NAC and formulations for drug delivery were also discussed, with the intent of advancing NAC-associated treatment modalities in oral medicine.
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U2 - 10.1155/2018/2835787
DO - 10.1155/2018/2835787
M3 - Review article
C2 - 29849877
AN - SCOPUS:85055079846
SN - 1942-0900
VL - 2018
JO - Oxidative medicine and cellular longevity
JF - Oxidative medicine and cellular longevity
M1 - 2835787
ER -
