Biomimetic analogs for collagen biomineralization

L. Gu, Y. K. Kim, Y. Liu, H. Ryou, C. E. Wimmer, L. Dai, D. D. Arola, S. W. Looney, D. H. Pashley, F. R. Tay

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Inability of chemical phosphorylation of sodium trimetaphosphate to induce intrafibrillar mineralization of type I collagen may be due to the failure to incorporate a biomimetic analog to stabilize amorphous calcium phosphates (ACP) as nanoprecursors. This study investigated adsorption/desorption characteristics of hydrolyzed and pH-adjusted sodium trimetaphosphate (HPA-Na3P 3O9) to collagen. Based on those results, a 5-minute treatment time with 2.8 wt% HPA-Na3P3O9 was used in a single-layer reconstituted collagen model to confirm that both the ACP-stabilization analog and matrix phosphoprotein analog must be present for intrafibrillar mineralization. The results of that model were further validated by complete remineralization of phosphoric-acid-etched dentin treated with the matrix phosphoprotein analog and lined with a remineralizing lining composite, and with the ACP-stabilization analog supplied in simulated body fluid. An understanding of the basic processes involved in intrafibrillar mineralization of reconstituted collagen fibrils facilitates the design of novel tissue engineering materials for hard tissue repair and regeneration.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalJournal of Dental Research
Issue number1
StatePublished - Jan 2011


  • biomimetic
  • biomineralization
  • chemical phosphorylation
  • collagen
  • specific binding

ASJC Scopus subject areas

  • Dentistry(all)


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